Nodal expression and detection in cancer: Experience and challenges

Luigi Strizzi; Katharine M. Hardy; Dawn A. Kirschmann; Lars Ahrlund-Richter; Mary J.C. Hendrix

doi:10.1158/0008-5472.CAN-11-3419

Nodal expression and detection in cancer: Experience and challenges

Luigi Strizzi, Katharine M. Hardy, Dawn A. Kirschmann, Lars Ahrlund-Richter, Mary J.C. Hendrix^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.

Original language	English (US)
Pages (from-to)	1915-1920
Number of pages	6
Journal	Cancer Research
Volume	72
Issue number	8
DOIs	https://doi.org/10.1158/0008-5472.CAN-11-3419
State	Published - Apr 15 2012

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1158/0008-5472.CAN-11-3419

Cite this

@article{5403ee7659ab46418b67a35c96b29b7c,

title = "Nodal expression and detection in cancer: Experience and challenges",

abstract = "Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.",

author = "Luigi Strizzi and Hardy, {Katharine M.} and Kirschmann, {Dawn A.} and Lars Ahrlund-Richter and Hendrix, {Mary J.C.}",

year = "2012",

month = apr,

day = "15",

doi = "10.1158/0008-5472.CAN-11-3419",

language = "English (US)",

volume = "72",

pages = "1915--1920",

journal = "Cancer Research",

issn = "0008-5472",

number = "8",

}

TY - JOUR

T1 - Nodal expression and detection in cancer

T2 - Experience and challenges

AU - Strizzi, Luigi

AU - Hardy, Katharine M.

AU - Kirschmann, Dawn A.

AU - Ahrlund-Richter, Lars

AU - Hendrix, Mary J.C.

PY - 2012/4/15

Y1 - 2012/4/15

N2 - Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.

AB - Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.

UR - http://www.scopus.com/inward/record.url?scp=84860133351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860133351&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-11-3419

DO - 10.1158/0008-5472.CAN-11-3419

M3 - Review article

C2 - 22508696

AN - SCOPUS:84860133351

SN - 0008-5472

VL - 72

SP - 1915

EP - 1920

JO - Cancer Research

JF - Cancer Research

IS - 8

ER -

Nodal expression and detection in cancer: Experience and challenges

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this