Nodal expression and detection in cancer: Experience and challenges

Luigi Strizzi, Katharine M. Hardy, Dawn A. Kirschmann, Lars Ahrlund-Richter, Mary J.C. Hendrix*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.

Original languageEnglish (US)
Pages (from-to)1915-1920
Number of pages6
JournalCancer Research
Volume72
Issue number8
DOIs
StatePublished - Apr 15 2012

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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