Noelin-1 is a secreted glycoprotein involved in generation of the neural crest

M. Barembaum*, T. A. Moreno, C. LaBonne, J. Sechrist, M. Bronner-Fraser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

The vertebrate neural crest arises at the border of the neural plate during early stages of nervous system development; however, little is known about the molecular mechanisms underlying neural crest formation. Here we identify a secreted protein, Noelin-1, which has the ability to prolong neural crest production. Noelin-1 messenger RNA is expressed in a graded pattern in the closing neural tube. It subsequently becomes restricted to the dorsal neural folds and migrating neural crest. Over expression of Noelin-1 using recombinant retroviruses causes an excess of neural crest emigration and extends the time that the neural tube is competent to generate as well as regenerate neural crest cells. These results support an important role for Noelin-1 in regulating the production of neural crest cells by the neural tube.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalNature Cell Biology
Volume2
Issue number4
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Cell Biology

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