Non-‘classical’ MEKs: A review of MEK3-7 inhibitors

Ada J. Kwong; Karl A. Scheidt

doi:10.1016/j.bmcl.2020.127203

Non-‘classical’ MEKs: A review of MEK3-7 inhibitors

Ada J. Kwong, Karl A. Scheidt^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

The MAPK pathways are an enduring area of interest due to their essential roles in cell processes. Increased expression and activity can lead to a multitude of diseases, sparking research efforts in developing inhibitors against these kinases. Though great strides have been made in developing MEK1/2 inhibitors, there is a notable lack of chemical probes for MEK3-7, given their central role in stimuli response, cell growth, and development. This review summarizes the progress that has been made on developing small molecule probes for MEK3-7, the specific disease states in which they have been studied, and their potential to become novel therapeutics.

Original language	English (US)
Article number	127203
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	30
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2020.127203
State	Published - Jul 1 2020

Keywords

Drug discovery
Kinases
Mitogen-activated protein kinases
Small molecule inhibitors
Structure-activity relationships

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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