Abstract
The MAPK pathways are an enduring area of interest due to their essential roles in cell processes. Increased expression and activity can lead to a multitude of diseases, sparking research efforts in developing inhibitors against these kinases. Though great strides have been made in developing MEK1/2 inhibitors, there is a notable lack of chemical probes for MEK3-7, given their central role in stimuli response, cell growth, and development. This review summarizes the progress that has been made on developing small molecule probes for MEK3-7, the specific disease states in which they have been studied, and their potential to become novel therapeutics.
Original language | English (US) |
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Article number | 127203 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 30 |
Issue number | 13 |
DOIs | |
State | Published - Jul 1 2020 |
Keywords
- Drug discovery
- Kinases
- Mitogen-activated protein kinases
- Small molecule inhibitors
- Structure-activity relationships
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry