Non-focal liver signal abnormalities on hepatobiliary phase of gadoxetate disodium-enhanced MR imaging: a review and differential diagnosis

Alessandro Furlan*, Amir A. Borhani, Matthew T. Heller, Robinson K. Yu, Mitchell E. Tublin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Gadoxetate disodium (Gd-EOB-DTPA) is a linear, non-ionic paramagnetic MR contrast agent with combined extracellular and hepatobiliary properties commonly used for several liver indications. Although gadoxetate disodium is commonly used for detection and characterization of focal lesions, a spectrum of diffuse disease processes can affect the hepatobiliary phase of imaging (i.e., when contrast accumulates within the hepatocytes). Non-focal signal abnormalities during the hepatobiliary phase can be seen with multiple disease processes such as deposition disorders, infiltrating tumors, vascular diseases, and post-treatment changes. The purpose of this paper is to review the different processes which result in non-focal signal alteration during the hepatobiliary phase and to describe imaging patterns that may order a differential diagnosis and facilitate patient management.

Original languageEnglish (US)
Pages (from-to)1399-1410
Number of pages12
JournalAbdominal Radiology
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • Gadoxetate disodium
  • Liver diseases
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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