Non-invasive measures of preclinical coronary heart disease

Philip Greenland*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter reviews four non-invasive tests for detection of preclinical coronary heart disease (CHD) and for prediction of future coronary events in asymptomatic people: (a) coronary artery calcium detection by ultrafast computed tomography; (b) ankle-brachial blood pressure index; (c) B-mode ultrasound of the carotid artery for measurement of intima-media thickness; and (d) exercise stress testing. Each of these modalities has been studied in large samples of asymptomatic people in whom considerable follow-up and multivariable adjustment are available to determine incremental predictive value beyond standard risk factor measures.

Original languageEnglish (US)
Title of host publicationCoronary Heart Disease Epidemiology
Subtitle of host publicationFrom Aetiology to Public Health
PublisherOxford University Press
ISBN (Electronic)9780191724114
ISBN (Print)9780198525738
StatePublished - Sep 1 2009


  • Asymptomatic people
  • Cardiovascular disease
  • Non-invasive testing
  • Preclinical CHD

ASJC Scopus subject areas

  • Psychology(all)


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