Non-invasive prenatal testing in the context of IVF and PGT-A

Dana Kimelman; Mary Ellen Pavone

doi:10.1016/j.bpobgyn.2020.07.004

Non-invasive prenatal testing in the context of IVF and PGT-A

Dana Kimelman, Mary Ellen Pavone^*

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

The high incidence of chromosome aneuploidy in human gametes and embryos is a major cause of in vitro fertilization (IVF) failure and miscarriage. In order to improve live birth rates with single embryo transfer, the use of preimplantation genetic testing for aneuploidy (PGT-A) has significantly increased. PGT encompasses methods that allow embryos to be tested for inherited conditions or screened for chromosomal abnormalities. However, PGT-A is a screening method and results can never be used to definitively predict the chromosomal status of the embryo and fetus. The objective of this manuscript is to review prenatal screening and diagnostic methods available in pregnancies conceived by IVF–PGT-A.

Original language	English (US)
Pages (from-to)	51-62
Number of pages	12
Journal	Best Practice and Research: Clinical Obstetrics and Gynaecology
Volume	70
DOIs	https://doi.org/10.1016/j.bpobgyn.2020.07.004
State	Published - Jan 2021

Keywords

Aneuploidy
CVS
Cell-free DNA
IVF
NIPT
PGT-A

ASJC Scopus subject areas

Obstetrics and Gynecology

Access to Document

10.1016/j.bpobgyn.2020.07.004

Cite this

@article{14dda74969f144ee89f36b095613bef4,

title = "Non-invasive prenatal testing in the context of IVF and PGT-A",

abstract = "The high incidence of chromosome aneuploidy in human gametes and embryos is a major cause of in vitro fertilization (IVF) failure and miscarriage. In order to improve live birth rates with single embryo transfer, the use of preimplantation genetic testing for aneuploidy (PGT-A) has significantly increased. PGT encompasses methods that allow embryos to be tested for inherited conditions or screened for chromosomal abnormalities. However, PGT-A is a screening method and results can never be used to definitively predict the chromosomal status of the embryo and fetus. The objective of this manuscript is to review prenatal screening and diagnostic methods available in pregnancies conceived by IVF–PGT-A.",

keywords = "Aneuploidy, CVS, Cell-free DNA, IVF, NIPT, PGT-A",

author = "Dana Kimelman and Pavone, {Mary Ellen}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = jan,

doi = "10.1016/j.bpobgyn.2020.07.004",

language = "English (US)",

volume = "70",

pages = "51--62",

journal = "Best Practice and Research: Clinical Obstetrics and Gynaecology",

issn = "1521-6934",

publisher = "Bailliere Tindall Ltd",

}

TY - JOUR

T1 - Non-invasive prenatal testing in the context of IVF and PGT-A

AU - Kimelman, Dana

AU - Pavone, Mary Ellen

PY - 2021/1

Y1 - 2021/1

N2 - The high incidence of chromosome aneuploidy in human gametes and embryos is a major cause of in vitro fertilization (IVF) failure and miscarriage. In order to improve live birth rates with single embryo transfer, the use of preimplantation genetic testing for aneuploidy (PGT-A) has significantly increased. PGT encompasses methods that allow embryos to be tested for inherited conditions or screened for chromosomal abnormalities. However, PGT-A is a screening method and results can never be used to definitively predict the chromosomal status of the embryo and fetus. The objective of this manuscript is to review prenatal screening and diagnostic methods available in pregnancies conceived by IVF–PGT-A.

AB - The high incidence of chromosome aneuploidy in human gametes and embryos is a major cause of in vitro fertilization (IVF) failure and miscarriage. In order to improve live birth rates with single embryo transfer, the use of preimplantation genetic testing for aneuploidy (PGT-A) has significantly increased. PGT encompasses methods that allow embryos to be tested for inherited conditions or screened for chromosomal abnormalities. However, PGT-A is a screening method and results can never be used to definitively predict the chromosomal status of the embryo and fetus. The objective of this manuscript is to review prenatal screening and diagnostic methods available in pregnancies conceived by IVF–PGT-A.

KW - Aneuploidy

KW - CVS

KW - Cell-free DNA

KW - IVF

KW - NIPT

KW - PGT-A

UR - http://www.scopus.com/inward/record.url?scp=85089145854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089145854&partnerID=8YFLogxK

U2 - 10.1016/j.bpobgyn.2020.07.004

DO - 10.1016/j.bpobgyn.2020.07.004

M3 - Review article

C2 - 32739290

AN - SCOPUS:85089145854

SN - 1521-6934

VL - 70

SP - 51

EP - 62

JO - Best Practice and Research: Clinical Obstetrics and Gynaecology

JF - Best Practice and Research: Clinical Obstetrics and Gynaecology

ER -

Non-invasive prenatal testing in the context of IVF and PGT-A

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this