Non-invasive prenatal testing in the context of IVF and PGT-A

Dana Kimelman, Mary Ellen Pavone*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The high incidence of chromosome aneuploidy in human gametes and embryos is a major cause of in vitro fertilization (IVF) failure and miscarriage. In order to improve live birth rates with single embryo transfer, the use of preimplantation genetic testing for aneuploidy (PGT-A) has significantly increased. PGT encompasses methods that allow embryos to be tested for inherited conditions or screened for chromosomal abnormalities. However, PGT-A is a screening method and results can never be used to definitively predict the chromosomal status of the embryo and fetus. The objective of this manuscript is to review prenatal screening and diagnostic methods available in pregnancies conceived by IVF–PGT-A.

Original languageEnglish (US)
Pages (from-to)51-62
Number of pages12
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
StatePublished - Jan 2021


  • Aneuploidy
  • CVS
  • Cell-free DNA
  • IVF
  • NIPT
  • PGT-A

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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