Non-lymphoma hematological malignancies in systemic lupus erythematosus

Mary Lu, Sasha Bernatsky, Rosalind Ramsey-Goldman, Michelle Petri, Susan Manzi, Murray B. Urowitz, Dafna Gladman, Paul R. Fortin, Ellen M. Ginzler, Edward Yelin, Sang Cheol Bae, Daniel J. Wallace, Soren Jacobsen, Mary Anne Dooley, Christine A. Peschken, Graciela S. Alarcón, Ola Nived, Lena Gottesman, Lindsey A. Criswell, Gunnar SturfeltLene Dreyer, Jennifer L. Lee, Ann E. Clarke

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalOncology (Switzerland)
Volume85
Issue number4
DOIs
StatePublished - Nov 1 2013

Keywords

  • Cancer
  • Malignancy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Lu, M., Bernatsky, S., Ramsey-Goldman, R., Petri, M., Manzi, S., Urowitz, M. B., Gladman, D., Fortin, P. R., Ginzler, E. M., Yelin, E., Bae, S. C., Wallace, D. J., Jacobsen, S., Dooley, M. A., Peschken, C. A., Alarcón, G. S., Nived, O., Gottesman, L., Criswell, L. A., ... Clarke, A. E. (2013). Non-lymphoma hematological malignancies in systemic lupus erythematosus. Oncology (Switzerland), 85(4), 235-240. https://doi.org/10.1159/000350165