Non-neoplastic findings

Daniel F.I. Kurtycz*, Paul N. Staats, Nancy A. Young, Marluce Bibbo, Terrence J. Colgan, Marianne U. Prey, Ritu Nayar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


The category “negative for intraepithelial lesion or malignancy” is used for specimens that show a spectrum of nonneoplastic changes, including those associated with protective and reactive responses to inflammation, hormonal alterations, and colonizing or infectious organisms. Recognition of the wide variety of normal cellular presentations is key for the accurate discrimination from neoplastic conditions. Many characteristic patterns of reaction in normal cells can be important clues to the underlying causative process. Some of these patterns have features which are also seen in neoplasia, hence recognition of the key reactive changes is essential for overall accuracy. An expanded variety of “normal” findings as well as non-neoplastic mimics of classic epithelial abnormalities are included in this chapter, providing a more complete representation of the morphologic variations that can be encountered in cervical cytology preparations.

Original languageEnglish (US)
Title of host publicationThe Bethesda System for Reporting Cervical Cytology
Subtitle of host publicationDefinitions, Criteria, and Explanatory Notes
PublisherSpringer International Publishing
Number of pages61
ISBN (Electronic)9783319110745
ISBN (Print)9783319110738
StatePublished - Jan 1 2015


  • Cervix
  • Cytology
  • NILM
  • Normal
  • Organisms
  • Pap
  • Reactive
  • Repair

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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