Non-Opioid Pharmacotherapy for Treatment of Pediatric Chronic Pain

David J. Krodel*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Opioid therapy is prescribed to children and adolescents with chronic pain due to lack of effective alternatives, insufficient understanding of nonopioid pharmacotherapy of chronic pain, and minimization of perceived risks of chronic opioid therapy in children and adolescents. Further exacerbating this problem, there are no FDA-approved indications for chronic pain for any nonopioid medication for patients under 18 years of age. Only a handful of medications commonly used for chronic pain have FDA approval for any indication in the under-18 population. Due to the paucity of well-conducted randomized controlled trials, adult data, empiricism, and provider-patient-family preferences guide the prescribing of these medications.

Original languageEnglish (US)
Title of host publicationOpioid Therapy in Infants, Children, and Adolescents
PublisherSpringer International Publishing
Number of pages16
ISBN (Electronic)9783030362874
ISBN (Print)9783030362867
StatePublished - Jan 1 2020


  • Adolescent pain
  • Nonmalignant chronic pain
  • Nonopioid pain therapy
  • Pediatric chronic pain
  • Pediatric opioid therapy

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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