Non-PmrA-mediated multidrug resistance in Streptococcus pneumoniae

Ekaterina Pestova*, John J. Millichap, Farida Siddiqui, Gary A. Noskin, Lance R. Peterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The PmrA multidrug transporter protein gene was inactivated in Streptococcus pneumoniae strains CP1000 (wild-type) and EBR (mutant with enhanced active multidrug efflux). While the resistance to fluoroquinolones and ethidium bromide shown by EBR was reduced to the wild-type level, neither the susceptibility to reserpine in the presence of ethidium bromide and selected fluoroquinolones, nor the ability to produce ethidium bromide-resistant mutants was eliminated in the CP1000 pmrA mutant, indicating the presence of an additional multidrug export protein(s).

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume49
Issue number3
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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