TY - GEN
T1 - Nonadherence to Oral Antihyperglycemic Agents
T2 - 15th World Congress on Health and Biomedical Informatics, MEDINFO 2015
AU - Zhu, Vivienne J.
AU - Tu, Wanzhu
AU - Rosenman, Marc B.
AU - Overhage, J. Marc
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Using real-world clinical data from the Indiana Network for Patient Care, we analyzed the associations between non-adherence to oral antihyperglycemic agents (OHA) and subsequent diabetes-related hospitalization and all-cause mortality for patients with type 2 diabetes. OHA adherence was measured by the annual proportion of days covered (PDC) for 2008 and 2009. Among 24,067 eligible patients, 35,507 annual PDCs were formed. Over 90% (n=21,798) of the patients had a PDC less than 80%. In generalized linear mixed model analyses, OHA non-adherence is significantly associated with diabetes related hospitalizations (OR: 1.2; 95% CI [1.1,1.3]; p<0.0001). Older patients, white patients, or patients who had ischemic heart disease, stroke, or renal disease had higher odds of hospitalization. Similarly, OHA non-adherence increased subsequent mortality (OR: 1.3; 95% CI [1.02, 1.61]; p<0.0001). Patient age, male gender, income and presence of ischemic heart diseases, stroke, and renal disease were also significantly associated with subsequent all-cause death.
AB - Using real-world clinical data from the Indiana Network for Patient Care, we analyzed the associations between non-adherence to oral antihyperglycemic agents (OHA) and subsequent diabetes-related hospitalization and all-cause mortality for patients with type 2 diabetes. OHA adherence was measured by the annual proportion of days covered (PDC) for 2008 and 2009. Among 24,067 eligible patients, 35,507 annual PDCs were formed. Over 90% (n=21,798) of the patients had a PDC less than 80%. In generalized linear mixed model analyses, OHA non-adherence is significantly associated with diabetes related hospitalizations (OR: 1.2; 95% CI [1.1,1.3]; p<0.0001). Older patients, white patients, or patients who had ischemic heart disease, stroke, or renal disease had higher odds of hospitalization. Similarly, OHA non-adherence increased subsequent mortality (OR: 1.3; 95% CI [1.02, 1.61]; p<0.0001). Patient age, male gender, income and presence of ischemic heart diseases, stroke, and renal disease were also significantly associated with subsequent all-cause death.
KW - Health information exchange
KW - hospitalization
KW - medication adherence
KW - mortality
KW - type 2 diabetes
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U2 - 10.3233/978-1-61499-564-7-60
DO - 10.3233/978-1-61499-564-7-60
M3 - Conference contribution
C2 - 26262010
AN - SCOPUS:84952049490
T3 - Studies in Health Technology and Informatics
SP - 60
EP - 63
BT - MEDINFO 2015
A2 - Georgiou, Andrew
A2 - Sarkar, Indra Neil
A2 - de Azevedo Marques, Paulo Mazzoncini
PB - IOS Press
Y2 - 19 August 2015 through 23 August 2015
ER -