Noncoding RNAs in cancer and cancer stem cells

Tianzhi Huang, Angel A Alvarez, Bo Hu*, Shi-Yuan Cheng

*Corresponding author for this work

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

In recent years, it has become increasingly apparent that noncoding RNAs (ncRNA) are of crucial importance for human cancer. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). miRNAs are endogenously expressed small RNA sequences that act as post-transcriptional regulators of gene expression and have been extensively studied for their roles in cancers, whereas lncRNAs are emerging as important players in the cancer paradigm in recent years. These noncoding genes are often aberrantly expressed in a variety of human cancers. However, the biological functions of most ncRNAs remain largely unknown. Recently, evidence has begun to accumulate describing how ncRNAs are dysregulated in cancer and cancer stem cells, a subset of cancer cells harboring self-renewal and differentiation capacities. These studies provide insight into the functional roles that ncRNAs play in tumor initiation, progression, and resistance to therapies, and they suggest ncRNAs as attractive therapeutic targets and potentially useful diagnostic tools.

Original languageEnglish (US)
Pages (from-to)582-593
Number of pages12
JournalChinese Journal of Cancer
Volume32
Issue number11
DOIs
StatePublished - Nov 15 2013

Fingerprint

Untranslated RNA
Neoplastic Stem Cells
Neoplasms
Long Noncoding RNA
MicroRNAs
Regulator Genes
Gene Expression
Therapeutics
Genes

Keywords

  • Cancer cell
  • Cancer stem cell
  • lncRNA
  • miRNA
  • ncRNA

ASJC Scopus subject areas

  • Oncology

Cite this

@article{4d0e43edab6c4696ab6db6ec757ae56d,
title = "Noncoding RNAs in cancer and cancer stem cells",
abstract = "In recent years, it has become increasingly apparent that noncoding RNAs (ncRNA) are of crucial importance for human cancer. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). miRNAs are endogenously expressed small RNA sequences that act as post-transcriptional regulators of gene expression and have been extensively studied for their roles in cancers, whereas lncRNAs are emerging as important players in the cancer paradigm in recent years. These noncoding genes are often aberrantly expressed in a variety of human cancers. However, the biological functions of most ncRNAs remain largely unknown. Recently, evidence has begun to accumulate describing how ncRNAs are dysregulated in cancer and cancer stem cells, a subset of cancer cells harboring self-renewal and differentiation capacities. These studies provide insight into the functional roles that ncRNAs play in tumor initiation, progression, and resistance to therapies, and they suggest ncRNAs as attractive therapeutic targets and potentially useful diagnostic tools.",
keywords = "Cancer cell, Cancer stem cell, lncRNA, miRNA, ncRNA",
author = "Tianzhi Huang and Alvarez, {Angel A} and Bo Hu and Shi-Yuan Cheng",
year = "2013",
month = "11",
day = "15",
doi = "10.5732/cjc.013.10170",
language = "English (US)",
volume = "32",
pages = "582--593",
journal = "Cancer Communications",
issn = "1000-467X",
publisher = "BioMed Central Ltd.",
number = "11",

}

Noncoding RNAs in cancer and cancer stem cells. / Huang, Tianzhi; Alvarez, Angel A; Hu, Bo; Cheng, Shi-Yuan.

In: Chinese Journal of Cancer, Vol. 32, No. 11, 15.11.2013, p. 582-593.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Noncoding RNAs in cancer and cancer stem cells

AU - Huang, Tianzhi

AU - Alvarez, Angel A

AU - Hu, Bo

AU - Cheng, Shi-Yuan

PY - 2013/11/15

Y1 - 2013/11/15

N2 - In recent years, it has become increasingly apparent that noncoding RNAs (ncRNA) are of crucial importance for human cancer. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). miRNAs are endogenously expressed small RNA sequences that act as post-transcriptional regulators of gene expression and have been extensively studied for their roles in cancers, whereas lncRNAs are emerging as important players in the cancer paradigm in recent years. These noncoding genes are often aberrantly expressed in a variety of human cancers. However, the biological functions of most ncRNAs remain largely unknown. Recently, evidence has begun to accumulate describing how ncRNAs are dysregulated in cancer and cancer stem cells, a subset of cancer cells harboring self-renewal and differentiation capacities. These studies provide insight into the functional roles that ncRNAs play in tumor initiation, progression, and resistance to therapies, and they suggest ncRNAs as attractive therapeutic targets and potentially useful diagnostic tools.

AB - In recent years, it has become increasingly apparent that noncoding RNAs (ncRNA) are of crucial importance for human cancer. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). miRNAs are endogenously expressed small RNA sequences that act as post-transcriptional regulators of gene expression and have been extensively studied for their roles in cancers, whereas lncRNAs are emerging as important players in the cancer paradigm in recent years. These noncoding genes are often aberrantly expressed in a variety of human cancers. However, the biological functions of most ncRNAs remain largely unknown. Recently, evidence has begun to accumulate describing how ncRNAs are dysregulated in cancer and cancer stem cells, a subset of cancer cells harboring self-renewal and differentiation capacities. These studies provide insight into the functional roles that ncRNAs play in tumor initiation, progression, and resistance to therapies, and they suggest ncRNAs as attractive therapeutic targets and potentially useful diagnostic tools.

KW - Cancer cell

KW - Cancer stem cell

KW - lncRNA

KW - miRNA

KW - ncRNA

UR - http://www.scopus.com/inward/record.url?scp=84887324286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887324286&partnerID=8YFLogxK

U2 - 10.5732/cjc.013.10170

DO - 10.5732/cjc.013.10170

M3 - Review article

C2 - 24206916

AN - SCOPUS:84887324286

VL - 32

SP - 582

EP - 593

JO - Cancer Communications

JF - Cancer Communications

SN - 1000-467X

IS - 11

ER -