Non‐cross‐reactivity of antibodies to murine LDH‐C4 with LDH‐A4 and LDH‐B4

Zhi‐Guo ‐G Liang, Joyce A. Shelton, Erwin Goldberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The induction of infertility by immunization with the sperm‐specific lactate dehydrogenase, LDH‐C4, suggests its use in a contraceptive vaccine. Development of an immunological contraceptive for human use, however, requires that there be no cross‐reactions with somatic tissues. We have demonstrated, using enzyme‐linked immunoabsorbence, solid‐phase radioimmunoassay, and competitive inhibition radioimmunoassay, that antisera to LDH‐C4 is specific and does not cross‐react with the somatic isozymes, LDH‐A4 and LDH‐B4.

Original languageEnglish (US)
Pages (from-to)377-384
Number of pages8
JournalJournal of Experimental Zoology
Issue number3
StatePublished - Dec 1986

ASJC Scopus subject areas

  • Animal Science and Zoology


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