The induction of infertility by immunization with the sperm‐specific lactate dehydrogenase, LDH‐C4, suggests its use in a contraceptive vaccine. Development of an immunological contraceptive for human use, however, requires that there be no cross‐reactions with somatic tissues. We have demonstrated, using enzyme‐linked immunoabsorbence, solid‐phase radioimmunoassay, and competitive inhibition radioimmunoassay, that antisera to LDH‐C4 is specific and does not cross‐react with the somatic isozymes, LDH‐A4 and LDH‐B4.
ASJC Scopus subject areas
- Animal Science and Zoology