Noninfectious vesicular stomatitis virus particles deficient in the viral nucleocapsid

T. J. Schnitzer, H. F. Lodish

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Several temperature-sensitive mutants of vesicular stomatitis virus in complementation group III produce, at nonpermissive temperature, noninfectious particles which contain the viral M (matrix) and G (glycoprotein) proteins but less than 10% of the normal proportion of N protein or RNA. Since group III mutants are thought to be defective in the structural gene for the virus M protein, these findings demonstrate that an interaction between M and the nucleocapsid is of importance in virus budding. Taken together with earlier results, they suggest that M is the key protein in bud formation.

Original languageEnglish (US)
Pages (from-to)443-447
Number of pages5
JournalJournal of virology
Volume29
Issue number2
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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