Noninvasive assessment of mitral inertance: Clinical results with numerical model validation

M. S. Firstenberg; N. L. Greenberg; N. G. Smedira; P. M. McCarthy; M. J. Garcia; J. D. Thomas

Noninvasive assessment of mitral inertance: Clinical results with numerical model validation

M. S. Firstenberg^*, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, M. J. Garcia, J. D. Thomas

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/D_RATIO) +0.063(LA_VOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.

Original language	English (US)
Pages (from-to)	613-616
Number of pages	4
Journal	Computers in Cardiology
State	Published - 2001
Event	Computer in Cardiology 2001 - Rotterdam, Netherlands Duration: Sep 23 2001 → Sep 26 2001

ASJC Scopus subject areas

Computer Science Applications
Cardiology and Cardiovascular Medicine

Cite this

@article{2099f7f8ef6e47fb8b5f3bc6e1f1a345,

title = "Noninvasive assessment of mitral inertance: Clinical results with numerical model validation",

abstract = "Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/DRATIO) +0.063(LAVOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.",

author = "Firstenberg, {M. S.} and Greenberg, {N. L.} and Smedira, {N. G.} and McCarthy, {P. M.} and Garcia, {M. J.} and Thomas, {J. D.}",

year = "2001",

language = "English (US)",

pages = "613--616",

journal = "Computers in Cardiology",

issn = "0276-6574",

publisher = "IEEE Computer Society",

note = "Computer in Cardiology 2001 ; Conference date: 23-09-2001 Through 26-09-2001",

}

TY - JOUR

T1 - Noninvasive assessment of mitral inertance

T2 - Computer in Cardiology 2001

AU - Firstenberg, M. S.

AU - Greenberg, N. L.

AU - Smedira, N. G.

AU - McCarthy, P. M.

AU - Garcia, M. J.

AU - Thomas, J. D.

PY - 2001

Y1 - 2001

N2 - Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/DRATIO) +0.063(LAVOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.

AB - Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/DRATIO) +0.063(LAVOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.

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M3 - Conference article

C2 - 14640109

AN - SCOPUS:0035715905

SN - 0276-6574

SP - 613

EP - 616

JO - Computers in Cardiology

JF - Computers in Cardiology

Y2 - 23 September 2001 through 26 September 2001

ER -

Noninvasive assessment of mitral inertance: Clinical results with numerical model validation

Abstract

ASJC Scopus subject areas

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