Noninvasive assessment of mitral inertance: Clinical results with numerical model validation

M. S. Firstenberg*, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, M. J. Garcia, J. D. Thomas

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/DRATIO) +0.063(LAVOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.

Original languageEnglish (US)
Pages (from-to)613-616
Number of pages4
JournalComputers in Cardiology
StatePublished - 2001
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001Sep 26 2001

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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