Noninvasive laser coagulation of the canine vas deferens, in vivo

Christopher M. Cilip, Ashley E. Ross, Jonathan P. Jarow, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Development of a noninvasive vasectomy technique may eliminate male fear of complications (incision, bleeding, infection, and scrotal pain) and result in a more popular procedure. This study builds upon previously reported ex vivo tissue studies by exploring acute and short-term chronic in vivo canine studies. Isolation of the canine vas was achieved using a conventional vas ring clamp method. No perforation of the scrotal skin was necessary to occlude the vas. Laser radiation with a wavelength of 1075 nm, average power of 11.2 W, 500-ms pulse duration, 0.5 Hz pulse rate, and 3-mm-diameter spot was synchronized with cryogen spray cooling of the scrotal skin surface in a total of 8 dogs (n = 16 vasa) for a treatment time of 60 s. Burst pressure measurements were conducted at Days 0 and 21 (n = 8 vasa each day) to quantify the strength of vas closure. The vas was successfully thermally occluded in 15/16 (94%) procedures with 14/15 (93%) vas recording burst pressures above ejaculation pressure. One vas was not present, and another vas recorded a bursting pressure below ejaculation pressure. The coagulated vas bursting pressure averaged 283 ± 34 mm Hg at Day 0 and 260 ± 77 mm Hg at Day 21, significantly higher than reported vas ejaculation pressures of 136 ± 29 mm Hg. Minor scrotal skin burns were observed during the recovery period. Noninvasive thermal occlusion of the vas is feasible in an in vivo canine model. Elimination of minor skin burns and longer term chronic in vivo canine studies are needed to confirm azospermia after vas occlusion without recanalization.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics VI
DOIs
StatePublished - 2010
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics VI - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7548
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics VI
CountryUnited States
CitySan Francisco, CA
Period1/23/101/25/10

Keywords

  • incision-less
  • laser
  • male sterilization
  • noninvasive
  • vasectomy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Cilip, C. M., Ross, A. E., Jarow, J. P., & Fried, N. M. (2010). Noninvasive laser coagulation of the canine vas deferens, in vivo. In Photonic Therapeutics and Diagnostics VI [75481D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7548). https://doi.org/10.1117/12.839601