Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex

J. Y. Wu, N. Salamon, H. E. Kirsch, M. M. Mantle, S. S. Nagarajan, L. Kurelowech, M. H. Aung, R. Sankar, W. D. Shields, G. W. Mathern

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


BACKGROUND: The unambiguous identification of the epileptogenic tubers in individuals with tuberous sclerosis complex (TSC) can be challenging. We assessed whether magnetic source imaging (MSI) and coregistration of fluorodeoxyglucose PET (FDG-PET) with MRI could improve the identification of the epileptogenic regions noninvasively in children with TSC. METHODS: In addition to standard presurgical evaluation, 28 children with intractable epilepsy from TSC referred from 2000 to 2007 had MSI and FDG-PET/MRI coregistration without extraoperative intracranial EEG. RESULTS: Based on the concordance of test results, 18 patients with TSC (64%) underwent surgical resection, with the final resection zone confirmed by intraoperative electrocorticography. Twelve patients are seizure free postoperatively (67%), with an average follow-up of 4.1 years. Younger age at surgery and shorter seizure duration were associated with postoperative seizure freedom. Conversely, older age and longer seizure duration were linked with continued seizures postoperatively or prevented surgery because of nonlateralizing or bilateral independent epileptogenic zones. Complete removal of presurgery MSI dipole clusters correlated with postoperative seizure freedom. CONCLUSIONS: Magnetic source imaging and fluorodeoxyglucose PET/MRI coregistration noninvasively localized the epileptogenic zones in many children with intractable epilepsy from tuberous sclerosis complex (TSC), with 67% seizure free postoperatively. Seizure freedom after surgery correlated with younger age and shorter seizure duration. These findings support the concept that early epilepsy surgery is associated with seizure freedom in children with TSC and intractable epilepsy.

Original languageEnglish (US)
Pages (from-to)392-398
Number of pages7
Issue number5
StatePublished - Feb 2010
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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