Noninvasive ventilation in chronic obstructive pulmonary disease

John M. Coleman*, Lisa F. Wolfe, Ravi Kalhan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The role of noninvasive positive pressure ventilation (NIV) in severe chronic obstructive pulmonary disease (COPD) has been controversial. Over the past two decades, data primarily obtained from Europe have begun to define the clinical characteristics of patients likely to respond, the role of high-intensity NIV, and the potential best timing of initiating therapy. These approaches, however, have not been validated in the context of the U.S. healthcare delivery system. Use of NIV in severe COPD in the United States is limited by the practicalities of doing in-hospital titrations as well as a complex system of reimbursement. These systematic complexities, coupled with a still-emerging clinical trial database regarding the most effective means to deliver NIV, have led to persistent uncertainty regarding when in stable severe COPD treatment with NIV is actually appropriate. In this review, we propose an assessment algorithm and treatment plan that can be used in clinical practice in the United States, but we acknowledge that the absence of pivotal clinical trials largely precludes a robust evidence-based approach to this potentially valuable therapy.

Original languageEnglish (US)
Pages (from-to)1091-1098
Number of pages8
JournalAnnals of the American Thoracic Society
Issue number9
StatePublished - 2019


  • Chronic hypercapnic respiratory failure
  • Home mechanical ventilation
  • Severe chronic obstructive pulmonary disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Noninvasive ventilation in chronic obstructive pulmonary disease'. Together they form a unique fingerprint.

Cite this