Nonlinear Connectivity in the Human Stretch Reflex Assessed by Cross-Frequency Phase Coupling

Yuan Yang, Teodoro Solis-Escalante, Jun Yao, Frans C.T. Van Der Helm, Julius P.A. Dewald, Alfred C. Schouten

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Communication between neuronal populations is facilitated by synchronization of their oscillatory activity. Although nonlinearity has been observed in the sensorimotor system, its nonlinear connectivity has not been widely investigated yet. This study investigates nonlinear connectivity during the human stretch reflex based on neuronal synchronization. Healthy participants generated isotonic wrist flexion while receiving a periodic mechanical perturbation to the wrist. Using a novel cross-frequency phase coupling metric, we estimate directional nonlinear connectivity, including time delay, from the perturbation to brain and to muscle, as well as from brain to muscle. Nonlinear phase coupling is significantly stronger from the perturbation to the muscle than to the brain, with a shorter time delay. The time delay from the perturbation to the muscle is 33 ms, similar to the reported latency of the spinal stretch reflex at the wrist. Source localization of nonlinear phase coupling from the brain to the muscle suggests activity originating from the motor cortex, although its effect on the stretch reflex is weak. As such nonlinear phase coupling between the perturbation and muscle activity is dominated by the spinal reflex loop. This study provides new evidence of nonlinear neuronal synchronization in the stretch reflex at the wrist joint with respect to spinal and transcortical loops.

Original languageEnglish (US)
Article number1650043
JournalInternational Journal of Neural Systems
Volume26
Issue number8
DOIs
StatePublished - Dec 1 2016

Fingerprint

Muscle
Brain
Time delay
Synchronization
Control nonlinearities
Nonlinear systems
Communication

Keywords

  • EEG
  • EMG
  • nonlinear connectivity
  • sensorimotor system
  • Stretch reflex
  • time delay

ASJC Scopus subject areas

  • Computer Networks and Communications

Cite this

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title = "Nonlinear Connectivity in the Human Stretch Reflex Assessed by Cross-Frequency Phase Coupling",
abstract = "Communication between neuronal populations is facilitated by synchronization of their oscillatory activity. Although nonlinearity has been observed in the sensorimotor system, its nonlinear connectivity has not been widely investigated yet. This study investigates nonlinear connectivity during the human stretch reflex based on neuronal synchronization. Healthy participants generated isotonic wrist flexion while receiving a periodic mechanical perturbation to the wrist. Using a novel cross-frequency phase coupling metric, we estimate directional nonlinear connectivity, including time delay, from the perturbation to brain and to muscle, as well as from brain to muscle. Nonlinear phase coupling is significantly stronger from the perturbation to the muscle than to the brain, with a shorter time delay. The time delay from the perturbation to the muscle is 33 ms, similar to the reported latency of the spinal stretch reflex at the wrist. Source localization of nonlinear phase coupling from the brain to the muscle suggests activity originating from the motor cortex, although its effect on the stretch reflex is weak. As such nonlinear phase coupling between the perturbation and muscle activity is dominated by the spinal reflex loop. This study provides new evidence of nonlinear neuronal synchronization in the stretch reflex at the wrist joint with respect to spinal and transcortical loops.",
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Nonlinear Connectivity in the Human Stretch Reflex Assessed by Cross-Frequency Phase Coupling. / Yang, Yuan; Solis-Escalante, Teodoro; Yao, Jun; Van Der Helm, Frans C.T.; Dewald, Julius P.A.; Schouten, Alfred C.

In: International Journal of Neural Systems, Vol. 26, No. 8, 1650043, 01.12.2016.

Research output: Contribution to journalArticle

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