Nonlinear Input-Output Functions of Motoneurons

Marc D. Binder; Randall K. Powers; C. J. Heckman

doi:10.1152/physiol.00026.2019

Nonlinear Input-Output Functions of Motoneurons

Marc D. Binder, Randall K. Powers, C. J. Heckman

Neuroscience

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

Original language	English (US)
Pages (from-to)	31-39
Number of pages	9
Journal	Physiology (Bethesda, Md.)
Volume	35
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00026.2019
State	Published - Jan 1 2020

Keywords

input-output function
motoneuron
nonlinear behavior
persistent inward currents

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00026.2019

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Nonlinear Input-Output Functions of Motoneurons

Abstract

Keywords

ASJC Scopus subject areas

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