Abstract
All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.
Original language | English (US) |
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Pages (from-to) | 31-39 |
Number of pages | 9 |
Journal | Physiology (Bethesda, Md.) |
Volume | 35 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- input-output function
- motoneuron
- nonlinear behavior
- persistent inward currents
ASJC Scopus subject areas
- Physiology