Nonlinear Input-Output Functions of Motoneurons

Marc D. Binder; Randall K. Powers; C. J. Heckman

doi:10.1152/physiol.00026.2019

Nonlinear Input-Output Functions of Motoneurons

Marc D. Binder, Randall K. Powers, C. J. Heckman

Physiology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

Original language	English (US)
Pages (from-to)	31-39
Number of pages	9
Journal	Physiology (Bethesda, Md.)
Volume	35
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00026.2019
State	Published - Jan 1 2020

Keywords

input-output function
motoneuron
nonlinear behavior
persistent inward currents

ASJC Scopus subject areas

Physiology

Access to Document

10.1152/physiol.00026.2019

Cite this

@article{c3b01b6214b046cda5c117a9399a3f9e,

title = "Nonlinear Input-Output Functions of Motoneurons",

abstract = "All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.",

keywords = "input-output function, motoneuron, nonlinear behavior, persistent inward currents",

author = "Binder, {Marc D.} and Powers, {Randall K.} and Heckman, {C. J.}",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2020",

month = jan,

day = "1",

doi = "10.1152/physiol.00026.2019",

language = "English (US)",

volume = "35",

pages = "31--39",

journal = "Physiology",

issn = "1548-9213",

publisher = "American Physiological Society",

number = "1",

}

TY - JOUR

T1 - Nonlinear Input-Output Functions of Motoneurons

AU - Binder, Marc D.

AU - Powers, Randall K.

AU - Heckman, C. J.

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2020/1/1

Y1 - 2020/1/1

N2 - All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

AB - All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.

KW - input-output function

KW - motoneuron

KW - nonlinear behavior

KW - persistent inward currents

UR - http://www.scopus.com/inward/record.url?scp=85076038732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076038732&partnerID=8YFLogxK

U2 - 10.1152/physiol.00026.2019

DO - 10.1152/physiol.00026.2019

M3 - Review article

C2 - 31799904

AN - SCOPUS:85076038732

VL - 35

SP - 31

EP - 39

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 1

ER -

Nonlinear Input-Output Functions of Motoneurons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this