Abstract
All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na+ and Ca2+ channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-39 |
| Number of pages | 9 |
| Journal | Physiology (Bethesda, Md.) |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2020 |
Keywords
- input-output function
- motoneuron
- nonlinear behavior
- persistent inward currents
ASJC Scopus subject areas
- Physiology
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Cite this
Binder, M. D., Powers, R. K., & Heckman, C. J. (2020). Nonlinear Input-Output Functions of Motoneurons. Physiology (Bethesda, Md.), 35(1), 31-39. https://doi.org/10.1152/physiol.00026.2019