@inproceedings{38b8d54a58cd46c6bd4161be21ca584b,
title = "Nonlinear responses in prestin knockout mice: implications for cochlear function",
abstract = "Construction of pseudotransducer functions in prestin knockout (KO) mice reveal that the outer hair cell (OHC) transducer appears to function normally, which allows one to study nonlinearities in mice that do not show frequency selectivity or amplification. Measurement of harmonic distortion indicates that the second harmonic exceeds the third in homozygotes and their controls. In addition, intermodulation distortion shows that the cubic difference tone (CDT), 2f1-f2, is ~20 dB down from f1 in both KO and wildtype (WT) mice. However, in contrast to controls where the cubic exceeds the quadratic difference tone (QDT, f2-f1), f2-f1 and 2f1-f2 are similar in magnitude for KO mice. Because KO mice also exhibit two-tone suppression, these results support the idea that cochlear nonlinearity persists in the absence of low thresholds and sharp tuning and that the hair cell transducer is the primary source of cochlear distortion.",
author = "Cheatham, {M. A.} and Huynh, {K. H.} and P. Dallos",
note = "Funding Information: Work supported by the NIDCD Grant #DC00089 and by the Hugh Knowles Center. We thank J.H. Siegel and M.A. Ruggero for comments on the manuscript. Publisher Copyright: Copyright {\textcopyright} 2006 by World Scientific Publishing Co. Pte. Ltd.; 9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 ; Conference date: 23-07-2005 Through 28-07-2005",
year = "2005",
language = "English (US)",
series = "Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium",
publisher = "World Scientific Publishing Co. Pte Ltd",
pages = "218--225",
editor = "Nuttall, {Alfred L.} and Tianying Ren and Peter Gillespie and Karl Grosh and {de Boer}, Egbert",
booktitle = "Auditory Mechanisms",
address = "Singapore",
}