Abstract
Construction of pseudotransducer functions in prestin knockout (KO) mice reveal that the outer hair cell (OHC) transducer appears to function normally, which allows one to study nonlinearities in mice that do not show frequency selectivity or amplification. Measurement of harmonic distortion indicates that the second harmonic exceeds the third in homozygotes and their controls. In addition, intermodulation distortion shows that the cubic difference tone (CDT), 2f1-f2, is ~20 dB down from f1 in both KO and wildtype (WT) mice. However, in contrast to controls where the cubic exceeds the quadratic difference tone (QDT, f2-f1), f2-f1 and 2f1-f2 are similar in magnitude for KO mice. Because KO mice also exhibit two-tone suppression, these results support the idea that cochlear nonlinearity persists in the absence of low thresholds and sharp tuning and that the hair cell transducer is the primary source of cochlear distortion.
Original language | English (US) |
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Title of host publication | Auditory Mechanisms |
Subtitle of host publication | Processes and Models - Proceedings of the 9th International Symposium |
Editors | Alfred L. Nuttall, Tianying Ren, Peter Gillespie, Karl Grosh, Egbert de Boer |
Publisher | World Scientific Publishing Co. Pte Ltd |
Pages | 218-225 |
Number of pages | 8 |
ISBN (Electronic) | 9812568247, 9789812568243 |
State | Published - 2005 |
Event | 9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 - Portland, United States Duration: Jul 23 2005 → Jul 28 2005 |
Publication series
Name | Auditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium |
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Conference
Conference | 9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 |
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Country/Territory | United States |
City | Portland |
Period | 7/23/05 → 7/28/05 |
Funding
Work supported by the NIDCD Grant #DC00089 and by the Hugh Knowles Center. We thank J.H. Siegel and M.A. Ruggero for comments on the manuscript.
ASJC Scopus subject areas
- Biotechnology
- Biomedical Engineering