Nonnuclear actions of estrogen

Karen J. Ho, James K. Liao*

*Corresponding author for this work

Research output: Contribution to journalShort survey

105 Citations (Scopus)

Abstract

Estrogen has long been observed to endow cardiovascular protective effects, as evidenced by sex-specific differences in the incidence of hypertensive and coronary artery disease, the development of atherosclerosis, and myocardial remodeling after infarction. To exert its tissue-specific effects, the classic estrogen receptor (ER) functions as a ligand-dependent transcription factor. However, there is growing evidence that in response to 17β-estradiol and heterologous signals, the ER can also mediate signaling cascades at the membrane and in the cytoplasm via various second messengers, such as receptor-mediated protein kinases. This review summarizes the current understanding of nonnuclear ER signaling and discusses the relevance to eliciting the beneficial cardiovascular effects of estrogen. These include vasodilation, inhibition of response to vessel injury, limiting myocardial injury after infarction, and attenuating cardiac hypertrophy. Defining the full repertoire of ER function promises to expose novel, highly specific targets for pharmacological interventions and may ultimately lead to the primary and secondary prevention of cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)1952-1961
Number of pages10
JournalArteriosclerosis, thrombosis, and vascular biology
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint

Estrogen Receptors
Estrogens
Infarction
Wounds and Injuries
Cardiomegaly
Second Messenger Systems
Primary Prevention
Secondary Prevention
Vasodilation
Sex Characteristics
Protein Kinases
Coronary Artery Disease
Estradiol
Atherosclerosis
Cytoplasm
Transcription Factors
Cardiovascular Diseases
Pharmacology
Ligands
Membranes

Keywords

  • Estrogen
  • Estrogen receptors
  • Signaling
  • Transcription
  • Vasculature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ho, Karen J. ; Liao, James K. / Nonnuclear actions of estrogen. In: Arteriosclerosis, thrombosis, and vascular biology. 2002 ; Vol. 22, No. 12. pp. 1952-1961.
@article{1b1763709ac947cfa4129edc098b72d8,
title = "Nonnuclear actions of estrogen",
abstract = "Estrogen has long been observed to endow cardiovascular protective effects, as evidenced by sex-specific differences in the incidence of hypertensive and coronary artery disease, the development of atherosclerosis, and myocardial remodeling after infarction. To exert its tissue-specific effects, the classic estrogen receptor (ER) functions as a ligand-dependent transcription factor. However, there is growing evidence that in response to 17β-estradiol and heterologous signals, the ER can also mediate signaling cascades at the membrane and in the cytoplasm via various second messengers, such as receptor-mediated protein kinases. This review summarizes the current understanding of nonnuclear ER signaling and discusses the relevance to eliciting the beneficial cardiovascular effects of estrogen. These include vasodilation, inhibition of response to vessel injury, limiting myocardial injury after infarction, and attenuating cardiac hypertrophy. Defining the full repertoire of ER function promises to expose novel, highly specific targets for pharmacological interventions and may ultimately lead to the primary and secondary prevention of cardiovascular diseases.",
keywords = "Estrogen, Estrogen receptors, Signaling, Transcription, Vasculature",
author = "Ho, {Karen J.} and Liao, {James K.}",
year = "2002",
month = "12",
day = "1",
doi = "10.1161/01.ATV.0000041200.85946.4A",
language = "English (US)",
volume = "22",
pages = "1952--1961",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

Nonnuclear actions of estrogen. / Ho, Karen J.; Liao, James K.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 22, No. 12, 01.12.2002, p. 1952-1961.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Nonnuclear actions of estrogen

AU - Ho, Karen J.

AU - Liao, James K.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Estrogen has long been observed to endow cardiovascular protective effects, as evidenced by sex-specific differences in the incidence of hypertensive and coronary artery disease, the development of atherosclerosis, and myocardial remodeling after infarction. To exert its tissue-specific effects, the classic estrogen receptor (ER) functions as a ligand-dependent transcription factor. However, there is growing evidence that in response to 17β-estradiol and heterologous signals, the ER can also mediate signaling cascades at the membrane and in the cytoplasm via various second messengers, such as receptor-mediated protein kinases. This review summarizes the current understanding of nonnuclear ER signaling and discusses the relevance to eliciting the beneficial cardiovascular effects of estrogen. These include vasodilation, inhibition of response to vessel injury, limiting myocardial injury after infarction, and attenuating cardiac hypertrophy. Defining the full repertoire of ER function promises to expose novel, highly specific targets for pharmacological interventions and may ultimately lead to the primary and secondary prevention of cardiovascular diseases.

AB - Estrogen has long been observed to endow cardiovascular protective effects, as evidenced by sex-specific differences in the incidence of hypertensive and coronary artery disease, the development of atherosclerosis, and myocardial remodeling after infarction. To exert its tissue-specific effects, the classic estrogen receptor (ER) functions as a ligand-dependent transcription factor. However, there is growing evidence that in response to 17β-estradiol and heterologous signals, the ER can also mediate signaling cascades at the membrane and in the cytoplasm via various second messengers, such as receptor-mediated protein kinases. This review summarizes the current understanding of nonnuclear ER signaling and discusses the relevance to eliciting the beneficial cardiovascular effects of estrogen. These include vasodilation, inhibition of response to vessel injury, limiting myocardial injury after infarction, and attenuating cardiac hypertrophy. Defining the full repertoire of ER function promises to expose novel, highly specific targets for pharmacological interventions and may ultimately lead to the primary and secondary prevention of cardiovascular diseases.

KW - Estrogen

KW - Estrogen receptors

KW - Signaling

KW - Transcription

KW - Vasculature

UR - http://www.scopus.com/inward/record.url?scp=0036929353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036929353&partnerID=8YFLogxK

U2 - 10.1161/01.ATV.0000041200.85946.4A

DO - 10.1161/01.ATV.0000041200.85946.4A

M3 - Short survey

VL - 22

SP - 1952

EP - 1961

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 12

ER -