Nonorgan manifestations of sarcoidosis

Jinny Tavee*, Daniel Culver

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Purpose of reviewThe current review discusses the diagnosis and management of nonorgan-related symptoms that commonly arise in the setting of systemic sarcoidosis. Fatigue, small fiber neuropathy (SFN) and neuropsychological symptoms are highlighted.Recent findingsThe debilitating effects of chronic nonorgan-based symptoms in sarcoidosis have led to recent studies focusing on incidence rates, contributing factors and potential therapeutic strategies. In a web-based survey of over 1000 sarcoidosis patients, the most common symptom was fatigue, which was reported by over 90% of participants, whereas memory loss and concentration problems were reported in 50%. SFN was also common, and may be diagnosed with tools such as skin biopsy measurement of intraepidermal nerve fibers and corneal confocal microscopy. In a recent cohort study of SFN patients, serologic evaluation demonstrated other contributing causes such as diabetes and vitamin B12 deficiency, which warrant-specific treatment. Finally, physical inactivity in patients with sarcoidosis correlated with lower quality-of-life (QOL) scores and possibly fatigue. Multidisciplinary programs that include physical therapy, patient education and psychological support were found to improve fatigue and mood disorders.SummaryRecognition of nonorgan-related symptoms and their impact on patient QOL is essential to optimal treatment of the sarcoidosis patient.

Original languageEnglish (US)
Pages (from-to)533-538
Number of pages6
JournalCurrent opinion in pulmonary medicine
Issue number5
StatePublished - Sep 1 2019


  • cognitive impairment
  • fatigue
  • sarcoidosis
  • small fiber neuropathy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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