Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi

Oriol Yélamos, Emily A. Merkel, Lauren Meldi Sholl, Bin Zhang, Sapna M. Amin, Christina Y. Lee, Gerta E. Guitart, Jingyi Yang, Alexander T. Wenzel, Christopher G. Bunick, Pedram Yazdan, Jaehyuk Choi, Pedram Gerami*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Genital melanomas (GM) are the second most common cancer of the female external genitalia and may be confused with atypical genital nevi (AGN), which exhibit atypical histological features but have benign behavior. In this study, we compared the clinical, histological, and molecular features of 19 GM and 25 AGN. We described chromosomal copy number aberrations and the mutational status of 50 oncogenes and tumor suppressor genes in both groups. Our study showed that a pigmented lesion occurring in mucosal tissue, particularly in postmenopausal women, was more likely to be a melanoma than a nevus. GM had high levels of chromosomal instability, with many copy number aberrations. Furthermore, we found a completely nonoverlapping pattern of oncogenic mutations when comparing GM and AGN. In GM, we report somatic mutations in KIT and TP53. Conversely, AGN had frequent BRAF V600E mutations, which were not seen in any of the GM. Our results show that GM and AGN have distinct clinical and molecular changes and that GM have a different mutational pattern compared with AGN.

Original languageEnglish (US)
Pages (from-to)1858-1865
Number of pages8
JournalJournal of Investigative Dermatology
Volume136
Issue number9
DOIs
StatePublished - Sep 1 2016

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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