Abstract
Nonphotic phase-shifting was studied in mice bearing the Clock mutation. First, free-running mice heterozygous for Clock and wild-type mice were induced to become active through a 4-h confinement to a novel running over 3 days. Second, mice exposed to light-dark cycle received daily hypocaloric food during 2 weeks, before being transferred to constant darkness and fed ad libitum. Behavioral activation during the mid-subjective day induced 40-min phase advances in the locomotor activity rhythm of wild-type mice, whereas it produced 50-min phase delays in the circadian behavior of Clock/+ mice. Calorie restriction phase-advanced by 80 min the locomotor activity rhythm in wild-type mice, but not in Clock/+ mice. Therefore, the response of the Clock/+ mice to nonphotic phase shifting differs from that of wild-type mice. Copyright (C) 2000 Elsevier Science B.V.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 398-403 |
| Number of pages | 6 |
| Journal | Brain research |
| Volume | 859 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 24 2000 |
Funding
The authors are grateful to Anne-Marie Chang and Sue Losee-Olson for expert assistance with genotyping. This work was supported by National Institute of Health Grants HL/MH-96015 and AG-11412 (FWT), US Army Research Office Grant DAAG55-98-1-0196 (FWT), NSF Center for Biological Timing Grant (JST) and an Unrestricted Research Grant in Neuroscience from Bristol-Myers Squibb (JST). JST is an investigator in the Howard Hughes Medical Institute.
Keywords
- Circadian rhythm
- Clock gene
- Light-entrainable pacemaker
- Locomotor behavior
- Photic synchronization
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- Clinical Neurology
- Molecular Biology
- General Neuroscience
- Developmental Biology