Nonradiographic axial spondyloarthritis: Clinical and therapeutic relevance

Nilasha Ghosh, Eric M. Ruderman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Current classification criteria for axial spondyloarthritis (axSpA) provide for the inclusion of patients with a wide range of presentations and manifestations. While not considered a formal subclassification, patients are often divided into radiographic or nonradiographic axSpA based on the presence or absence of radiographic sacroiliitis. This review will focus on nonradiographic axSpA and will discuss clinical manifestations of disease that distinguish, or in many cases do not distinguish, this entity from other individuals with axSpA. This review will also cover treatment paradigms for nonradiographic axSpA, particularly the use of biologic therapies, where current data suggest that nonradiographic disease should be managed largely the same as radiographic disease, or classical ankylosing spondylitis.

Original languageEnglish (US)
Article number286
JournalArthritis Research and Therapy
Issue number1
StatePublished - Dec 22 2017


  • Axial spondyloarthritis
  • Biologic therapy
  • Disease classification
  • Nonradiographic axial spondyloarthritis
  • Therapy

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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