Nonsteroidal Anti-inflammatory Drugs in Ophthalmology

Stephen J. Kim*, Allan J. Flach, Lee M. Jampol

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

247 Scopus citations

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are increasingly employed in ophthalmology to reduce miosis and inflammation, manage scleritis, and prevent and treat cystoid macular edema associated with cataract surgery. In addition, they may decrease postoperative pain and photophobia associated with refractive surgery and may reduce the itching associated with allergic conjunctivitis. In recent years, the U.S. Food and Drug Administration has approved new topical NSAIDs, and previously approved NSAIDs have been reformulated. These additions and changes result in different pharmacokinetics and dosing intervals, which may offer therapeutic advantages. For example, therapeutic effects on diabetic retinopathy and age-related macular degeneration may now be achievable. We provide an updated review on NSAIDs and a summary of their current uses in ophthalmology with attention to potential future applications.

Original languageEnglish (US)
Pages (from-to)108-133
Number of pages26
JournalSurvey of ophthalmology
Volume55
Issue number2
DOIs
StatePublished - Mar 4 2010

Keywords

  • NSAIDs
  • age-related macular degeneration
  • allergic conjunctivitis
  • cataract surgery
  • cyclooxygenase inhibitors
  • cystoid macular edema
  • diabetic retinopathy
  • mydriasis
  • nonsteroidal anti-inflammatory drugs
  • postoperative inflammation
  • prostaglandins

ASJC Scopus subject areas

  • Ophthalmology

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