Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Issue number||9 I|
|State||Published - 1983|
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