Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

S. K. Datta, B. D. Stollar, R. S. Schwartz

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

Original languageEnglish (US)
Pages (from-to)2723-2727
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number9 I
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • General

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