Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

S. K. Datta; B. D. Stollar; R. S. Schwartz

doi:10.1073/pnas.80.9.2723

Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

S. K. Datta, B. D. Stollar, R. S. Schwartz

Medicine, Rheumatology Division

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75 Scopus citations

Abstract

Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

Original language	English (US)
Pages (from-to)	2723-2727
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	80
Issue number	9 I
DOIs	https://doi.org/10.1073/pnas.80.9.2723
State	Published - 1983

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title = "Normal mice express idiotypes related to autoantibody idiotypes of lupus mice",

abstract = "Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.",

author = "Datta, {S. K.} and Stollar, {B. D.} and Schwartz, {R. S.}",

year = "1983",

doi = "10.1073/pnas.80.9.2723",

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AU - Datta, S. K.

AU - Stollar, B. D.

AU - Schwartz, R. S.

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N2 - Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

AB - Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

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Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

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