Normal postexercise facilitation and depression of motor evoked potentials in postpolio patients

A. Samii, J. Lopez-Devine, E. M. Wasserman, M. C. Dalakas, K. Clark, J. Grafman, M. Hallett*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations


We studied the effects of exercise on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation in healthy subjects and postpolio patients. Subjects performed repeated sets of isometric exercise until the muscle fatigued. In both groups, the mean MEP amplitude immediately after each exercise set was approximately twice that of the baseline amplitude, indicating similar postexercise facilitation, and after fatigue was approximately half that of the baseline amplitude, indicating similar postexercise depression. We conclude that the intracortical component of central fatigue is normal in postpolio patients.

Original languageEnglish (US)
Pages (from-to)948-950
Number of pages3
JournalMuscle and Nerve
Issue number7
Publication statusPublished - Jul 1 1998



  • Human
  • Motor evoked potential
  • Postexercise depression
  • Postexercise facilitation
  • Postpolio
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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