Normalization of ejection fraction and resolution of symptoms in chronic severe heart failure is possible with modern medical therapy: Clinical observations in 11 patients

Matthew E. Harinstein, Jennifer I. Berliner, Sanjiv J Shah, Heinrich Taegtmeyer, Mihai Gheorghiade*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This report describes the normalization of left ventricular ejection fraction and resolution of signs and symptoms of chronic and severe heart failure in both male and female patients (mean age 54 years) treated with standard medical therapy. These observations were made in 11 patients with idiopathic dilated cardiomyopathy treated in a single cardiology practice, who had evidence of myocardial "viability" (dysfunctional but noncontractile myocardium that has the potential for improvement in function) as assessed by cardiac magnetic resonance imaging, low-dose dobutamine echocardiography, or nuclear imaging. These patients were treated with standard available therapies including β-blockers, angiotensin-converting enzyme inhibitors, digoxin, and potassium and non-potassiumsparing diuretics. The average ejection fraction at presentation was 17% 6 9% which improved to 59% ± 5%. All patients improved to New York Heart Association functional class I with available therapy. The majority of patients received micronutrient supplementation with coenzyme Q10, vitamin B1, and amino acids, which target the pathways of cardiac metabolism and may aid in the restoration of cardiac function. This case series demonstrates that normalization of cardiac function is possible with standard therapy and the importance of assessing myocardial viability in all patients with heart failure and reduced ejection fraction. Given the unique metabolic needs of the failing heart, the role of micronutrients in combination with standard therapy warrants further investigation.

Original languageEnglish (US)
Pages (from-to)206-213
Number of pages8
JournalAmerican journal of therapeutics
Volume15
Issue number3
DOIs
StatePublished - May 1 2008

Keywords

  • Heart failure
  • Metabolism
  • Micronutrients
  • Myocardial viability

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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