TY - JOUR
T1 - Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
AU - Canu, Elisa
AU - Agosta, Federica
AU - Imperiale, Francesca
AU - Ferraro, Pilar M.
AU - Fontana, Andrea
AU - Magnani, Giuseppe
AU - Mesulam, Marek Marsel
AU - Thompson, Cynthia K.
AU - Weintraub, Sandra
AU - Moro, Andrea
AU - Cappa, Stefano F.
AU - Filippi, Massimo
N1 - Funding Information:
C.K. Thompson is an Action Editor of Cortex ; receives research support from the National Institutes of Health (NIH) Institute for Deafness and other Communication Disorders (NIDCD); has received speaker honoraria from the American Speech-Language-Hearing Association , Temple University , the University of Arizona and other many US and international institutions, and remuneration for consulting services from Beijing Language and Culture University and the Chinese Stroke Association .
Funding Information:
The study was supported by the Italian Ministry of Health (grant number GR-2011-02351217) and in part by RO1 DC008552 (Mesulam, PI).F. Agosta is Section Editor of NeuroImage: Clinical; has received speaker honoraria from Biogen Idec and Novartis; and receives or has received research supports from the Italian Ministry of Health, AriSLA (Fondazione Italiana di Ricerca per la SLA), and the European Research Council.M.M. Mesulam receives research funding from the National Institutes of Health, USA.C.K. Thompson is an Action Editor of Cortex; receives research support from the National Institutes of Health (NIH) Institute for Deafness and other Communication Disorders (NIDCD); has received speaker honoraria from the American Speech-Language-Hearing Association, Temple University, the University of Arizona and other many US and international institutions, and remuneration for consulting services from Beijing Language and Culture University and the Chinese Stroke Association.S.F. Cappa is Section Editor of Cortex; has received compensation for consulting services and/or speaking activities from Biogen, Roche, Eli-Lilly, Nutricia; and receives research support from the Italian Ministry of Health and Medical Research Council.
Funding Information:
S.F. Cappa is Section Editor of Cortex ; has received compensation for consulting services and/or speaking activities from Biogen, Roche, Eli-Lilly, Nutricia; and receives research support from the Italian Ministry of Health and Medical Research Council .
Funding Information:
M.M. Mesulam receives research funding from the National Institutes of Health , USA.
Funding Information:
The study was supported by the Italian Ministry of Health (grant number GR-2011-02351217 ) and in part by RO1 DC008552 (Mesulam, PI).
Funding Information:
F. Agosta is Section Editor of NeuroImage : Clinical ; has received speaker honoraria from Biogen Idec and Novartis ; and receives or has received research supports from the Italian Ministry of Health, AriSLA (Fondazione Italiana di Ricerca per la SLA), and the European Research Council .
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/10
Y1 - 2019/10
N2 - Objectives: To test the ability of the Northwestern Anagram Test-Italian (NAT-I) to distinguish between the non-fluent/agrammatic (nfv-) and phonological/logopenic (lv-) variants of primary progressive aphasia (PPA), and to determine the relationship between NAT-I variables and brain integrity in PPA patients. Methods: 13 nfvPPA and 8 lvPPA patients underwent the 44-item-version of NAT-I and brain MRI. The NAT-I was also administered to six patients with the semantic variant (sv) PPA to sample performance in cases with no grammatical deficits. Performances were recorded and compared between patient groups. Receiver Operating Characteristic curve analysis assessed the ability of NAT-I to discriminate nfvPPA and lvPPA. The correlation between anatomical changes and NAT-I variables were assessed. A shortened (22-item)-version of NAT-I was also tested for classification ability. Results: Participants with NfvPPA performed more poorly than lvPPA patients on canonical and non-canonical sentences. NAT-I non-canonical sentence and total scores achieved the highest diagnostic accuracy in discriminating the two patient groups (area under the curve:.93 and.91, respectively). SvPPA participants showed performances similar to lvPPA. NAT-I variables correlated with the integrity of the left inferior frontal gyrus and the body of the corpus callosum. The NAT-I 22-item-version total and non-canonical sentences scores reached diagnostic accuracy comparable to the full version. Conclusions: The NAT-I, in particular the measure of non-canonical syntax, is an effective tool for distinguishing nfvPPA and lvPPA patients and correlated with the integrity of crucial brain regions implicated in syntactic processing. The 22-item-brief version of NAT-I is suitable for clinical practice and research.
AB - Objectives: To test the ability of the Northwestern Anagram Test-Italian (NAT-I) to distinguish between the non-fluent/agrammatic (nfv-) and phonological/logopenic (lv-) variants of primary progressive aphasia (PPA), and to determine the relationship between NAT-I variables and brain integrity in PPA patients. Methods: 13 nfvPPA and 8 lvPPA patients underwent the 44-item-version of NAT-I and brain MRI. The NAT-I was also administered to six patients with the semantic variant (sv) PPA to sample performance in cases with no grammatical deficits. Performances were recorded and compared between patient groups. Receiver Operating Characteristic curve analysis assessed the ability of NAT-I to discriminate nfvPPA and lvPPA. The correlation between anatomical changes and NAT-I variables were assessed. A shortened (22-item)-version of NAT-I was also tested for classification ability. Results: Participants with NfvPPA performed more poorly than lvPPA patients on canonical and non-canonical sentences. NAT-I non-canonical sentence and total scores achieved the highest diagnostic accuracy in discriminating the two patient groups (area under the curve:.93 and.91, respectively). SvPPA participants showed performances similar to lvPPA. NAT-I variables correlated with the integrity of the left inferior frontal gyrus and the body of the corpus callosum. The NAT-I 22-item-version total and non-canonical sentences scores reached diagnostic accuracy comparable to the full version. Conclusions: The NAT-I, in particular the measure of non-canonical syntax, is an effective tool for distinguishing nfvPPA and lvPPA patients and correlated with the integrity of crucial brain regions implicated in syntactic processing. The 22-item-brief version of NAT-I is suitable for clinical practice and research.
KW - Logopenic PPA variant
KW - Magnetic Resonance Imaging (MRI)
KW - Nonfluent PPA variant
KW - Northwestern Anagram Test (NAT)
KW - Primary progressive aphasia (PPA)
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U2 - 10.1016/j.cortex.2019.08.007
DO - 10.1016/j.cortex.2019.08.007
M3 - Article
C2 - 31527011
AN - SCOPUS:85072230989
VL - 119
SP - 497
EP - 510
JO - Cortex
JF - Cortex
SN - 0010-9452
ER -