Notch: Of mice and men?

Sebastien Malinge*, John D Crispino

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations


A recent study has demonstrated that Notch is a positive regulator of murine megakaryopoiesis.1 In this issue of Blood, Poirault-Chassac et al report the opposite: Notch inhibits the terminal differentiation of human megakaryocytes.2 Does this discrepancy arise from species-specific activities of Notch or a difference in experimental design?

Original languageEnglish (US)
Pages (from-to)5438-5439
Number of pages2
Issue number25
StatePublished - Dec 16 2010

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology


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