Notch: Of mice and men?

Sebastien Malinge; John Crispino

doi:10.1182/blood-2010-09-308395

Notch: Of mice and men?

Sebastien Malinge^*, John Crispino

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

A recent study has demonstrated that Notch is a positive regulator of murine megakaryopoiesis.¹ In this issue of Blood, Poirault-Chassac et al report the opposite: Notch inhibits the terminal differentiation of human megakaryocytes.² Does this discrepancy arise from species-specific activities of Notch or a difference in experimental design?

Original language	English (US)
Pages (from-to)	5438-5439
Number of pages	2
Journal	Blood
Volume	116
Issue number	25
DOIs	https://doi.org/10.1182/blood-2010-09-308395
State	Published - Dec 16 2010

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

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10.1182/blood-2010-09-308395

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title = "Notch: Of mice and men?",

abstract = "A recent study has demonstrated that Notch is a positive regulator of murine megakaryopoiesis.1 In this issue of Blood, Poirault-Chassac et al report the opposite: Notch inhibits the terminal differentiation of human megakaryocytes.2 Does this discrepancy arise from species-specific activities of Notch or a difference in experimental design?",

author = "Sebastien Malinge and John Crispino",

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doi = "10.1182/blood-2010-09-308395",

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T1 - Notch

T2 - Of mice and men?

AU - Malinge, Sebastien

AU - Crispino, John

PY - 2010/12/16

Y1 - 2010/12/16

N2 - A recent study has demonstrated that Notch is a positive regulator of murine megakaryopoiesis.1 In this issue of Blood, Poirault-Chassac et al report the opposite: Notch inhibits the terminal differentiation of human megakaryocytes.2 Does this discrepancy arise from species-specific activities of Notch or a difference in experimental design?

AB - A recent study has demonstrated that Notch is a positive regulator of murine megakaryopoiesis.1 In this issue of Blood, Poirault-Chassac et al report the opposite: Notch inhibits the terminal differentiation of human megakaryocytes.2 Does this discrepancy arise from species-specific activities of Notch or a difference in experimental design?

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DO - 10.1182/blood-2010-09-308395

M3 - Comment/debate

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SN - 0006-4971

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JO - Blood

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IS - 25

ER -

Notch: Of mice and men?

Abstract

ASJC Scopus subject areas

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