Novel 3,4- and 8,15-polyether analogues of macrocyclic trichothecenes

Derek W. Anderson*, Robin M. Black, David A. Leigh, J. Fraser Stoddart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Protecting group chemistry on derivatives of T-2 toxin (2) involving silylation (TBDMS ethers) of the hydroxyl groups at C-3 and C-4, and acetalation (benzylidene acetals) of the C-8 and C-15 hydroxyl groups, has afforded the 3,4- and 8,15-polyether analogues 9-12 and 18 and 19 of macrocyclic trichothecenes.

Original languageEnglish (US)
Pages (from-to)2657-2660
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number23
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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