Novel Agents for Chemoprevention, Screening Methods, and Sampling Issues

Mary Jo Fackler, Ella Evron, Seema Ahsan Khan, Saraswati Sukumar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

An aggressive approach to breast cancer control based on preventing the disease must complement efforts at effective treatment. To date clinical trials testing new chemopreventative agents have not generally met with the kind of success expected. A wide range of new breast cancer chemopreventative agents are poised to be tested in clinical trials. We review these novel agents and approaches, including those for which clinical trials have been initiated and those that are promising in the preclinical arena. Further progress in this area requires not only new agents, but novel methods for screening for risk assessment, sampling and development of intermediate biomarkers. We review these novel potential surrogate endpoints, including new imaging techniques, breast sampling approaches, and methods to assess biomarkers in breast epithelium. Factors that could contribute to a meaningful choice of the chemopreventive agents and the design of clinical trials are discussed.

Original languageEnglish (US)
Pages (from-to)75-89
Number of pages15
JournalJournal of Mammary Gland Biology and Neoplasia
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Breast cancer
  • Ductal lavage
  • Early detection
  • Prevention
  • Sampling

ASJC Scopus subject areas

  • Cancer Research

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