Novel Approach to Tracking Mutant Huntingtin in Biosamples

Katarina Trajkovic, Dimitri Krainc*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

Although the established causative agent in Huntington's disease (HD) is a mutation in a single gene encoding huntingtin protein, the pathogenic cascade preceding neuronal death and disease onset is both incompletely understood and clinically undetectable. A new article published in Molecular Cell explores mutant huntingtin (mHtt) aggregate seeding activity as an early pathogenesis-tracking parameter with potential biomarker quality.

Original languageEnglish (US)
Pages (from-to)978-981
Number of pages4
JournalTrends in Molecular Medicine
Volume24
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • Huntington's disease
  • biomarker
  • mutant huntingtin
  • seeding aggregation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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