Novel device to change left ventricular shape for heart failure treatment: Device design and implantation procedure

Masami Takagaki, Patrick M. McCarthy*, Yoshie Ochiai, Raymond Dessoffy, Kazuyoshi Doi, Robert Vidlund, Todd J. Mortier, Cyril J. Schweich, Kiyotaka Fukamachi

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The Myocor Myosplint is designed to decrease left ventricular (LV) wall stress by changing LV shape, thus improving contractile function in dilated hearts. This shape change is accomplished by surgically placing three Myosplints perpendicular to the LV long axis, drawing the LV walls inward, and creating a symmetric, bilobular LV. Specially designed instruments aid in the precise delivery of these devices. The purpose of this study was to test the safety and feasibility of the procedure in dogs. Dilated cardiomyopathy was induced in 40 healthy dogs (26.3 ± 1.7 kg) by ventricular pacing at 230 beats per minute for an average of 25 ± 4 days. Using epicardial echocardiography, we placed the Myosplints across the LV chamber, avoiding the major coronary arteries, papillary muscles, and mitral valve. Once placed, the Myosplints were used to draw the LV walls inward to a prescribed distance. In all cases, we successfully implanted three Myosplints without using cardiopulmonary bypass. There were no complications related to the device or procedure. Myosplint implantation to change LV shape is safe and repeatable on a beating cardiomyopathic canine heart. Further study of the procedure will be needed in humans.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalASAIO Journal
Volume47
Issue number3
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Takagaki, M., McCarthy, P. M., Ochiai, Y., Dessoffy, R., Doi, K., Vidlund, R., Mortier, T. J., Schweich, C. J., & Fukamachi, K. (2001). Novel device to change left ventricular shape for heart failure treatment: Device design and implantation procedure. ASAIO Journal, 47(3), 244-248. https://doi.org/10.1097/00002480-200105000-00017