Novel epigenetic link between gestational diabetes mellitus and macrosomia

Brian T. Joyce*, Huikun Liu, Leishen Wang, Jun Wang, Yinan Zheng, Drew Nannini, Alex Drong, Stephanie Shiau, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Andrea Baccarelli, Gang Hu, Lifang Hou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes IGF1, IGF2, H19, ARHGRF11, MEST, NR3C1, ADIPOQ and RETN. Materials & methods: A total of 1145 children (572 GDM cases and 573 controls) from the Tianjin GDM study, including 177 with macrosomia, had blood DNA collection at median age 5.9 (range: 3.1-10.0). We used logistic regression to screen for associations with GDM and model macrosomia on 37 CpGs, and performed mediation analysis. Results: One CpG was associated with macrosomia at false discovery rate (FDR) <0.05 (cg14428359 in MEST); two (cg19466922 in MEST and cg26263166 in IGF2) were associated at p < 0.05 but mediated 26 and 13%, respectively. Conclusion: MEST and IGF2 were previously identified for potential involvement in fetal growth and development (Trial Registration number: NCT01554358 [ClinicalTrials.gov]).

Original languageEnglish (US)
Pages (from-to)1221-1230
Number of pages10
JournalEpigenomics
Volume13
Issue number15
DOIs
StatePublished - Aug 2021

Keywords

  • epigenetic epidemiology
  • epigenetics
  • macrosomia
  • metabolic diseases
  • pediatrics

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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