Novel function of STAT1 in breast cancer

Ming Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In the past, the transcription factor ST AT1 was considered as a tumor suppressor. We have recently discovered that ST AT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloidderived suppressor cells (MDSCs). Inhibiting ST AT1 activity offers a promising therapeutic approach against advanced breast cancer.

Original languageEnglish (US)
Article numbere25125
JournalOncoImmunology
Volume2
Issue number8
DOIs
StatePublished - Oct 22 2013

Keywords

  • Breast cancer
  • Immunosuppression
  • MDSCS
  • STAT1
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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