Novel function of STAT1 in breast cancer

Ming Zhang

doi:10.4161/onci.25125

Novel function of STAT1 in breast cancer

Ming Zhang^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In the past, the transcription factor ST AT1 was considered as a tumor suppressor. We have recently discovered that ST AT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloidderived suppressor cells (MDSCs). Inhibiting ST AT1 activity offers a promising therapeutic approach against advanced breast cancer.

Original language	English (US)
Article number	e25125
Journal	OncoImmunology
Volume	2
Issue number	8
DOIs	https://doi.org/10.4161/onci.25125
State	Published - 2013

Keywords

Breast cancer
Immunosuppression
MDSCS
STAT1
T cell

ASJC Scopus subject areas

Oncology
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.25125

Cite this

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title = "Novel function of STAT1 in breast cancer",

abstract = "In the past, the transcription factor ST AT1 was considered as a tumor suppressor. We have recently discovered that ST AT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloidderived suppressor cells (MDSCs). Inhibiting ST AT1 activity offers a promising therapeutic approach against advanced breast cancer.",

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AB - In the past, the transcription factor ST AT1 was considered as a tumor suppressor. We have recently discovered that ST AT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloidderived suppressor cells (MDSCs). Inhibiting ST AT1 activity offers a promising therapeutic approach against advanced breast cancer.

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KW - Immunosuppression

KW - MDSCS

KW - STAT1

KW - T cell

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JF - OncoImmunology

IS - 8

M1 - e25125

ER -

Novel function of STAT1 in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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