Novel pharmacologic approaches to the management of sepsis: Targeting the host inflammatory response

Derek S. Wheeler*, Basilia Zingarelli, William J. Wheeler, Hector R. Wong

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Sepsis is currently the 10th leading cause of death overall and accounts for significant healthcare expenditures in the developed world. There are now more deaths attributable to sepsis than coronary artery disease, stroke, or cancer, and it is widely believed that the incidence of sepsis and sepsis-related mortality will continue to rise. Based on these sobering statistics, there is great interest in identifying novel treatments for managing critically ill children and adults with sepsis. Unfortunately, to date, there have been very few successful therapeutic agents employed in the clinical setting. Despite these disappointing results, new therapeutic agents continue to be identified, and there is reason for optimism and hope for the future. Herein, we will briefly review several novel therapeutic adjuncts for the management of critically ill patients with sepsis. We will largely focus on those therapies that directly target the host inflammatory response, specifically those that result in activation of the transcription factor, nuclear factor (NF)-κB. We will also reference some of the patents recently filed that pertain to the host innate immune response and sepsis.

Original languageEnglish (US)
Pages (from-to)96-112
Number of pages17
JournalRecent Patents on Inflammation and Allergy Drug Discovery
Issue number2
StatePublished - 2009


  • Adult
  • Critical illness
  • Danger signals
  • Gene polymorphisms
  • Genomics
  • Heat shock proteins
  • Inflammation
  • LPS
  • NF-κB
  • Pediatric
  • Sepsis
  • Septic shock
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Drug Discovery

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