Novel phenotypic markers and screening score for the metabolic syndrome in adult Asian Indians

Anoop Misra*, Abhishek Jaiswal, Divya Shakti, Jasjeet Wasir, Naval Kishor Vikram, Ravindra Mohan Pandey, Dimple Kondal, Bharat Bhushan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Aims: The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are common in Asian Indians. Simple yet reliable phenotypic markers are needed for early detection of the MS in Asian Indians. Methods: In this cross-sectional study, 126 subjects either with of without the MS were compared. Anthropometric measurements (including assessment of novel phenotypic markers) and metabolic profile were done. Results: On univariate analysis, age more than 35 year, female gender, presence of buffalo hump and double chin and family history of T2DM were significantly associated with the MS. A metabolic syndrome screening (MSS) score (1.0 × double chin + 1.2 × buffalo hump + 1.3 × gender + 1.4 × age category) was generated with a cutoff value of 3.5 out of total points of 4.9, with sensitivity and specificity 82% and 71% [area under the curve = 0.83; 95% confidence Interval (0.76-0.90)], respectively in detecting individuals with the MS. Conclusion: We describe buffalo hump and double chin as novel phenotypic markers for detection of MS for the first time. The MSS score generated by us may be a useful tool for detection of MS in adult Asian Indians; however, it needs further validation in a larger sample of Asian Indians and in other ethnic groups.

Original languageEnglish (US)
Pages (from-to)e1-e5
JournalDiabetes Research and Clinical Practice
Issue number2
StatePublished - Feb 2008


  • Asian Indians
  • Buffalo hump
  • Diabetes
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Novel phenotypic markers and screening score for the metabolic syndrome in adult Asian Indians'. Together they form a unique fingerprint.

Cite this