TY - JOUR
T1 - Novel phenotypic markers and screening score for the metabolic syndrome in adult Asian Indians
AU - Misra, Anoop
AU - Jaiswal, Abhishek
AU - Shakti, Divya
AU - Wasir, Jasjeet
AU - Vikram, Naval Kishor
AU - Pandey, Ravindra Mohan
AU - Kondal, Dimple
AU - Bhushan, Bharat
PY - 2008/2
Y1 - 2008/2
N2 - Aims: The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are common in Asian Indians. Simple yet reliable phenotypic markers are needed for early detection of the MS in Asian Indians. Methods: In this cross-sectional study, 126 subjects either with of without the MS were compared. Anthropometric measurements (including assessment of novel phenotypic markers) and metabolic profile were done. Results: On univariate analysis, age more than 35 year, female gender, presence of buffalo hump and double chin and family history of T2DM were significantly associated with the MS. A metabolic syndrome screening (MSS) score (1.0 × double chin + 1.2 × buffalo hump + 1.3 × gender + 1.4 × age category) was generated with a cutoff value of 3.5 out of total points of 4.9, with sensitivity and specificity 82% and 71% [area under the curve = 0.83; 95% confidence Interval (0.76-0.90)], respectively in detecting individuals with the MS. Conclusion: We describe buffalo hump and double chin as novel phenotypic markers for detection of MS for the first time. The MSS score generated by us may be a useful tool for detection of MS in adult Asian Indians; however, it needs further validation in a larger sample of Asian Indians and in other ethnic groups.
AB - Aims: The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are common in Asian Indians. Simple yet reliable phenotypic markers are needed for early detection of the MS in Asian Indians. Methods: In this cross-sectional study, 126 subjects either with of without the MS were compared. Anthropometric measurements (including assessment of novel phenotypic markers) and metabolic profile were done. Results: On univariate analysis, age more than 35 year, female gender, presence of buffalo hump and double chin and family history of T2DM were significantly associated with the MS. A metabolic syndrome screening (MSS) score (1.0 × double chin + 1.2 × buffalo hump + 1.3 × gender + 1.4 × age category) was generated with a cutoff value of 3.5 out of total points of 4.9, with sensitivity and specificity 82% and 71% [area under the curve = 0.83; 95% confidence Interval (0.76-0.90)], respectively in detecting individuals with the MS. Conclusion: We describe buffalo hump and double chin as novel phenotypic markers for detection of MS for the first time. The MSS score generated by us may be a useful tool for detection of MS in adult Asian Indians; however, it needs further validation in a larger sample of Asian Indians and in other ethnic groups.
KW - Asian Indians
KW - Buffalo hump
KW - Diabetes
KW - Insulin resistance
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U2 - 10.1016/j.diabres.2007.08.002
DO - 10.1016/j.diabres.2007.08.002
M3 - Article
C2 - 17881078
AN - SCOPUS:38349102455
SN - 0168-8227
VL - 79
SP - e1-e5
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 2
ER -
