Novel regulation and function of Src tyrosine kinase

Y. C. Ma, X. Y. Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Src tyrosine kinase is a critical signal transducer that modulates a wide variety of cellular functions. Misregulation of Src leads to cell transformation and cancer. Heterotrimeric guanine-nucleotide-binding proteins (G proteins) are another group of signaling molecules that transduce signals from cell-surface receptors to generate physiological responses. Recently, it was discovered that Gαs and Gαi could directly stimulate Src family tyrosine kinase activity. This novel regulation of Src tyrosine kinase by G proteins provides insights into the adenylyl cyclase-independent signaling mechanisms involved in ligand-induced receptor desensitization, internalization and other physiological processes.

Original languageEnglish (US)
Pages (from-to)456-462
Number of pages7
JournalCellular and Molecular Life Sciences
Volume59
Issue number3
DOIs
StatePublished - Apr 11 2002

Keywords

  • Adenylyl cyclase
  • G protein
  • Receptor desensitization
  • Receptor internalization
  • Src tyrosine kinase

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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