Abstract
β -Adrenergic receptors transduce signals through the heterotrimeric G protein Gαs to regulate cardiac function. Recently, it has been discovered that Gαs could directly stimulate the Src family tyrosine kinase activity. This novel signaling pathway provides insights into the cAMP-PKA-independent signaling mechanisms used by β -adrenergic receptors to regulate apoptosis, receptor desensitization, and other physiological functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 46-49 |
| Number of pages | 4 |
| Journal | Trends in Cardiovascular Medicine |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2002 |
Funding
We thank Dr. Svetlana Cvejic and William E. Lowry for reading the manuscript. Research in our lab is supported by grants from the NIH (AG14563 and GM56904), the American Cancer Society, and the Dorothy Rodbell Cohen Foundation for Sarcoma Research. X.-Y.H. is an Established Investigator of the American Heart Association and a Career Scientist of the Irma T. Hirschl Trust.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
