Novel signaling pathway through the β-adrenergic receptor

Yong Chao Ma, Xin Yun Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

β -Adrenergic receptors transduce signals through the heterotrimeric G protein Gαs to regulate cardiac function. Recently, it has been discovered that Gαs could directly stimulate the Src family tyrosine kinase activity. This novel signaling pathway provides insights into the cAMP-PKA-independent signaling mechanisms used by β -adrenergic receptors to regulate apoptosis, receptor desensitization, and other physiological functions.

Original languageEnglish (US)
Pages (from-to)46-49
Number of pages4
JournalTrends in Cardiovascular Medicine
Volume12
Issue number1
DOIs
StatePublished - 2002

Funding

We thank Dr. Svetlana Cvejic and William E. Lowry for reading the manuscript. Research in our lab is supported by grants from the NIH (AG14563 and GM56904), the American Cancer Society, and the Dorothy Rodbell Cohen Foundation for Sarcoma Research. X.-Y.H. is an Established Investigator of the American Heart Association and a Career Scientist of the Irma T. Hirschl Trust.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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