Novel strategies for diagnosis of glioblastoma multiforme

Adam M. Sonabend, Jonathan Yun, Peter Canoll, Jeffrey N. Bruce

Research output: Contribution to journalReview articlepeer-review


Glioblastoma multiforme (GBM) is the most common of all primary brain tumors and has the worst prognosis. Increased understanding of glioma biology and pathophysiology has translated into interesting advances in the diagnostic approach for patients bearing these tumors. This review explores the clinical, radiographic, and histological features of GBM that aid in its identification, with an emphasis on the application of emerging technologies. The use of novel imaging modalities including magnetic resonance imaging (MRI) spectroscopy, positron emission tomography, and perfusion MRI are discussed along with a review of tumor genetics and epigenetics from the perspective of their diagnostic and prognostic relevance.

Original languageEnglish (US)
JournalEuropean journal of Clinical and Medical Oncology
Issue number2
StatePublished - 2010


  • Diagnosis
  • Genetics
  • Glioblastoma multiforme
  • Glioma
  • Magnetic resonance imaging (MRI)
  • Magnetic resonance spectroscopy (MRS)

ASJC Scopus subject areas

  • Oncology


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