Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents

Stephen L. Gwaltney*, Hovis M. Imade, Kenneth J. Barr, Qun Li, Laura Gehrke, R. Bruce Credo, Robert B. Warner, Jang Yun Lee, Peter Kovar, Jieyi Wang, Michael A. Nukkala, Nicolette A. Zielinski, David Frost, Shi Chung Ng, Hing L. Sham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.

Original languageEnglish (US)
Pages (from-to)871-874
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
StatePublished - Apr 9 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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