Novel targets for spinal cord injury related neuropathic pain

Mostafa M. Ahmed, Kevin C. King, Shane M. Pearce, Melissa A. Ramsey, Gurwattan S. Miranpuri, Daniel K. Resnick

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Millions of people suffer from spinal cord injury (SCI) with little known effective clinical therapy. Neuropathic pain (NP) is often accompanied with SCI, making clinical treatment challenging. Even though the key mediators in the development of NP have been discovered, the pathogenesis is still unclear. Some of the key mediators in the sustenance of NP include the inflammatory processes, cannabinoid receptors, matrix metalloproteases, and their tissue inhibitors. Animal models have shown promising results with modulation of these mediators, yet the clinical models have been unsuccessful. One such study with matrix metalloproteases (MMPs) has yielded encouraging results. The relationship between MMPs and their tissue inhibitors (TIMPs) plays a significant role in the pathogenesis and recovery of SCI and the CNS. Key factors that lead to the functional consequences of MMP activity are cellular localization, tissue distribution, and temporal pattern of MMP expression. Studies concluding that MMPs can be seen as contributors of tissue damage and as contributors in the repair mechanisms have provided a need to reexamine their roles after acute and chronic neuropathic pain.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalAnnals of Neurosciences
Volume18
Issue number4
DOIs
StatePublished - Oct 1 2011

Keywords

  • MMPS
  • Neuropathic pain
  • Spinal cord injury
  • TIMPS

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Ahmed, M. M., King, K. C., Pearce, S. M., Ramsey, M. A., Miranpuri, G. S., & Resnick, D. K. (2011). Novel targets for spinal cord injury related neuropathic pain. Annals of Neurosciences, 18(4), 162-167. https://doi.org/10.5214/ans.0972.7531.1118413