TY - JOUR
T1 - Novel thromboresistant materials
AU - Jordan, Sumanas W.
AU - Chaikof, Elliot L.
PY - 2007/6
Y1 - 2007/6
N2 - The development of a clinically durable small-diameter vascular graft as well as permanently implantable biosensors and artificial organ systems that interface with blood, including the artificial heart, kidney, liver, and lung, remain limited by surface-induced thrombotic responses. Recent breakthroughs in materials science, along with a growing understanding of the molecular events that underlay thrombosis, has led to the design and clinical evaluation of a variety of biologically active coatings that inhibit components of the coagulation pathway and platelet responses by surface immobilization or controlled release of bioactive agents. This report reviews recent progress in generating synthetic thromboresistant surfaces that inhibit (1) protein and cell adsorption, (2) thrombin and fibrin formation, and (3) platelet activation and aggregation.
AB - The development of a clinically durable small-diameter vascular graft as well as permanently implantable biosensors and artificial organ systems that interface with blood, including the artificial heart, kidney, liver, and lung, remain limited by surface-induced thrombotic responses. Recent breakthroughs in materials science, along with a growing understanding of the molecular events that underlay thrombosis, has led to the design and clinical evaluation of a variety of biologically active coatings that inhibit components of the coagulation pathway and platelet responses by surface immobilization or controlled release of bioactive agents. This report reviews recent progress in generating synthetic thromboresistant surfaces that inhibit (1) protein and cell adsorption, (2) thrombin and fibrin formation, and (3) platelet activation and aggregation.
UR - http://www.scopus.com/inward/record.url?scp=34249319466&partnerID=8YFLogxK
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U2 - 10.1016/j.jvs.2007.02.048
DO - 10.1016/j.jvs.2007.02.048
M3 - Article
C2 - 17544031
AN - SCOPUS:34249319466
SN - 0741-5214
VL - 45
SP - A104-A115
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 6 SUPPL.
ER -