Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study

Irene Tracey, Lino Becerra, Iwen Chang, Hans Breiter, Liane Jenkins, David Borsook, R. Gilberto González*

*Corresponding author for this work

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

We used functional magnetic resonance imaging (fMRI) to determine whether similar brain regions activate during noxious hot and cold stimulation. Six male subjects underwent whole brain fMRI during phasic delivery of noxious hot (46°C) and noxious cold (5°C) stimulation to the dorsum of the left hand. Mid-brain regions activated included thalamus, basal ganglia and insula. Cortical areas activated included cingulate, somatosensory, premotor and motor cortices, as well as prefrontal and inferior parietal cortex. Most regions activated bilaterally but with stronger activation contralateral to the stimulus. Noxious cold stimulation produced significantly increased volumes of activation compared to noxious heat in prefrontal areas only. Our results suggest a similar network of regions activate common to the perception of pain produced by either noxious hot or cold stimulation. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalNeuroscience Letters
Volume288
Issue number2
DOIs
StatePublished - Jul 14 2000

Keywords

  • Brain
  • Brain imaging
  • Functional magnetic resonance imaging
  • Pain
  • Thermal

ASJC Scopus subject areas

  • Neuroscience(all)

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