Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study

Irene Tracey; Lino Becerra; Iwen Chang; Hans Breiter; Liane Jenkins; David Borsook; R. Gilberto González

doi:10.1016/S0304-3940(00)01224-6

Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study

Irene Tracey, Lino Becerra, Iwen Chang, Hans Breiter, Liane Jenkins, David Borsook, R. Gilberto González^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

We used functional magnetic resonance imaging (fMRI) to determine whether similar brain regions activate during noxious hot and cold stimulation. Six male subjects underwent whole brain fMRI during phasic delivery of noxious hot (46°C) and noxious cold (5°C) stimulation to the dorsum of the left hand. Mid-brain regions activated included thalamus, basal ganglia and insula. Cortical areas activated included cingulate, somatosensory, premotor and motor cortices, as well as prefrontal and inferior parietal cortex. Most regions activated bilaterally but with stronger activation contralateral to the stimulus. Noxious cold stimulation produced significantly increased volumes of activation compared to noxious heat in prefrontal areas only. Our results suggest a similar network of regions activate common to the perception of pain produced by either noxious hot or cold stimulation. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	159-162
Number of pages	4
Journal	Neuroscience Letters
Volume	288
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(00)01224-6
State	Published - Jul 14 2000

Keywords

Brain
Brain imaging
Functional magnetic resonance imaging
Pain
Thermal

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01224-6

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title = "Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study",

abstract = "We used functional magnetic resonance imaging (fMRI) to determine whether similar brain regions activate during noxious hot and cold stimulation. Six male subjects underwent whole brain fMRI during phasic delivery of noxious hot (46°C) and noxious cold (5°C) stimulation to the dorsum of the left hand. Mid-brain regions activated included thalamus, basal ganglia and insula. Cortical areas activated included cingulate, somatosensory, premotor and motor cortices, as well as prefrontal and inferior parietal cortex. Most regions activated bilaterally but with stronger activation contralateral to the stimulus. Noxious cold stimulation produced significantly increased volumes of activation compared to noxious heat in prefrontal areas only. Our results suggest a similar network of regions activate common to the perception of pain produced by either noxious hot or cold stimulation. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Brain, Brain imaging, Functional magnetic resonance imaging, Pain, Thermal",

author = "Irene Tracey and Lino Becerra and Iwen Chang and Hans Breiter and Liane Jenkins and David Borsook and Gonz{\'a}lez, {R. Gilberto}",

note = "Funding Information: Support for this research was provided by NIH grants DE12734 (DB), DA012581 (RGG), NS34626 (RGG), RR13213(RGG), the Freeman Fund, Department of Neurology (DB), the Mel Fisher Fund (DB), the Florey Fund (IT). We thank M. Foley, T. Campbell and P.M. Matthews for their help. ",

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doi = "10.1016/S0304-3940(00)01224-6",

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T2 - A functional magnetic resonance imaging study

AU - Tracey, Irene

AU - Becerra, Lino

AU - Chang, Iwen

AU - Breiter, Hans

AU - Jenkins, Liane

AU - Borsook, David

AU - González, R. Gilberto

N1 - Funding Information: Support for this research was provided by NIH grants DE12734 (DB), DA012581 (RGG), NS34626 (RGG), RR13213(RGG), the Freeman Fund, Department of Neurology (DB), the Mel Fisher Fund (DB), the Florey Fund (IT). We thank M. Foley, T. Campbell and P.M. Matthews for their help.

PY - 2000/7/14

Y1 - 2000/7/14

N2 - We used functional magnetic resonance imaging (fMRI) to determine whether similar brain regions activate during noxious hot and cold stimulation. Six male subjects underwent whole brain fMRI during phasic delivery of noxious hot (46°C) and noxious cold (5°C) stimulation to the dorsum of the left hand. Mid-brain regions activated included thalamus, basal ganglia and insula. Cortical areas activated included cingulate, somatosensory, premotor and motor cortices, as well as prefrontal and inferior parietal cortex. Most regions activated bilaterally but with stronger activation contralateral to the stimulus. Noxious cold stimulation produced significantly increased volumes of activation compared to noxious heat in prefrontal areas only. Our results suggest a similar network of regions activate common to the perception of pain produced by either noxious hot or cold stimulation. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - We used functional magnetic resonance imaging (fMRI) to determine whether similar brain regions activate during noxious hot and cold stimulation. Six male subjects underwent whole brain fMRI during phasic delivery of noxious hot (46°C) and noxious cold (5°C) stimulation to the dorsum of the left hand. Mid-brain regions activated included thalamus, basal ganglia and insula. Cortical areas activated included cingulate, somatosensory, premotor and motor cortices, as well as prefrontal and inferior parietal cortex. Most regions activated bilaterally but with stronger activation contralateral to the stimulus. Noxious cold stimulation produced significantly increased volumes of activation compared to noxious heat in prefrontal areas only. Our results suggest a similar network of regions activate common to the perception of pain produced by either noxious hot or cold stimulation. Copyright (C) 2000 Elsevier Science Ireland Ltd.

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KW - Thermal

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Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study

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