@article{993345036c1d48649674b0dbb28d40e1,
title = "Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin",
abstract = "α-Catenin is an F-actin-binding protein widely recognized for its role in cell-cell adhesion. However, a growing body of literature indicates that α-catenin is also a nuclear protein. In this study, we show that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenindependent manner and requires nuclear actin polymerization. These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the α-catenin-β-catenin complex in the nucleus.",
keywords = "DNA damage, Nuclear actin, WNT, α-Catenin, β-Catenin",
author = "Serebryannyy, {Leonid A.} and Alex Yemelyanov and Gottardi, {Cara J.} and {de Lanerolle}, Primal",
note = "Funding Information: We thank Drs Pierre-Alexandre Vidi (Wake Forest) and Veronika Butin-Israeli (Northwestern University) for their critical insight into the design of this study. The CBC-UIC Research Resources Center Mass spectrometry, Metabolomics and Proteomics Facility was established in part by a grant from The Searle Funds at the Chicago Community Trust to the Chicago Biomedical Consortium.This work was supported by National Institutes of Health (GM80587 to P.d.L.; GM076561 to C.J.G.), the Chicago Biomedical Consortium with support from the Searle Funds at The Chicago Community Trust (to P.d.L. as co-principal investigator), the Northwestern University Physical Sciences Oncology Center associated with National Cancer Institute (U54CA143869 to C.J.G. and P.d.L.), the American Heart Association (AHA) (13PRE17050060), a Chicago Biomedical Consortium Scholar award, UIC Dean's Scholar, and Chancellor's graduate research fellowship (to L.S.). Deposited in PMC for release after 12 months. Publisher Copyright: {\textcopyright} 2017. Published by The Company of Biologists Ltd.",
year = "2017",
month = may,
day = "15",
doi = "10.1242/jcs.199893",
language = "English (US)",
volume = "130",
pages = "1717--1729",
journal = "The Quarterly journal of microscopical science",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "10",
}