Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

Leonid A. Serebryannyy*, Alex Yemelyanov, Cara J. Gottardi, Primal de Lanerolle

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

α-Catenin is an F-actin-binding protein widely recognized for its role in cell-cell adhesion. However, a growing body of literature indicates that α-catenin is also a nuclear protein. In this study, we show that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenindependent manner and requires nuclear actin polymerization. These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the α-catenin-β-catenin complex in the nucleus.

Original languageEnglish (US)
Pages (from-to)1717-1729
Number of pages13
JournalJournal of cell science
Volume130
Issue number10
DOIs
Publication statusPublished - May 15 2017

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Keywords

  • DNA damage
  • Nuclear actin
  • WNT
  • α-Catenin
  • β-Catenin

ASJC Scopus subject areas

  • Cell Biology

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