Nuclear lamin functions and disease

Veronika Butin-Israeli*, Stephen A Adam, Anne E. Goldman, Robert Goldman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations

Abstract

Recent studies have shown that premature cellular senescence and normal organ development and function depend on the type V intermediate filament proteins, the lamins, which are major structural proteins of the nucleus. This review presents an up-to-date summary of the literature describing new findings on lamin functions in various cellular processes and emphasizes the relationship between the lamins and devastating diseases ranging from premature aging to cancer. Recent insights into the structure and function of the A- and B- type lamins in normal cells and their dysfunctions in diseased cells are providing novel targets for the development of new diagnostic procedures and disease intervention. We summarize these recent findings, focusing on data from mice and humans, and highlight the expanding knowledge of these proteins in both healthy and diseased cells.

Original languageEnglish (US)
Pages (from-to)464-471
Number of pages8
JournalTrends in Genetics
Volume28
Issue number9
DOIs
StatePublished - Sep 1 2012

Keywords

  • HGPS
  • Laminopathies
  • Lamins
  • Progerin

ASJC Scopus subject areas

  • Genetics

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