Nuclear lamins.

Thomas Dechat*, Stephen A. Adam, Pekka Taimen, Takeshi Shimi, Robert D. Goldman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

238 Scopus citations

Abstract

The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization. The developmentally regulated expression of lamins suggests that they are involved in cellular differentiation. Their assembly dynamic properties throughout the cell cycle, particularly in mitosis, are influenced by posttranslational modifications. Lamins may regulate nuclear functions by direct interactions with chromatin and determining the spatial organization of chromosomes within the nuclear space. They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription.

Original languageEnglish (US)
Pages (from-to)a000547
JournalCold Spring Harbor Perspectives in Biology
Volume2
Issue number11
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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